Actively Recruiting

Phase Not Applicable
Age: 18Years +
FEMALE
NCT07378319

Dextrose Hydrodissection for Post-Breast Cancer Chest Wall and Axillary Tightness.

Led by Taichung Veterans General Hospital · Updated on 2026-03-20

15

Participants Needed

1

Research Sites

76 weeks

Total Duration

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AI-Summary

What this Trial Is About

The goal of this clinical trial (prospective case series) is to evaluate the feasibility, safety, and preliminary clinical outcomes of ultrasound-guided dextrose prolotherapy in female breast cancer survivors with persistent ipsilateral chest wall and axillary pain and tightness who have plateaued with standard physical therapy. The main questions it aims to answer are: Does ultrasound-guided dextrose prolotherapy significantly improve upper extremity functional limitation (measured by the QuickDASH questionnaire)? What are the effects of this intervention on pain intensity (NRS), active shoulder range of motion (AROM), and anterior chest wall soft-tissue tightness (pectoralis minor muscle length)? Participants will: Undergo a comprehensive baseline physical examination and ultrasound assessment of the symptomatic chest wall and axilla. Receive three sessions of ultrasound-guided 5% dextrose injections into targeted soft-tissue planes at 4-week intervals. Continue their designated standard rehabilitation program, including range-of-motion and stretching exercises. Attend follow-up assessments at 4-week intervals during the treatment phase, with long-term follow-up at 3 and 6 months after the final injection to evaluate the durability of the response.

CONDITIONS

Official Title

Dextrose Hydrodissection for Post-Breast Cancer Chest Wall and Axillary Tightness.

Who Can Participate

Age: 18Years +
FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • History of breast cancer surgery (mastectomy or breast-conserving surgery), with or without axillary lymph node dissection
  • Persistent ipsilateral chest wall and/or axillary pain, tightness, or movement restriction lasting 23 3 months after surgery
  • Clinically significant baseline symptoms with QuickDASH score 25 25 and/or pain intensity 25 5/10 on Numeric Rating Scale
  • Completion of 12 weeks of standard physical therapy without significant improvement (less than 15 point QuickDASH improvement and/or less than 2 point pain improvement)
  • Age 18 years or older
  • Ability to provide written informed consent
Not Eligible

You will not qualify if you...

  • Evidence of local cancer recurrence or metastatic disease
  • Active lymphedema requiring ongoing decongestive therapy
  • Shoulder conditions judged to be the main cause of symptoms (e.g., adhesive capsulitis, acute rotator cuff tear)
  • Active infection, skin lesion, or unhealed wound at the injection site
  • Known bleeding disorders or use of anticoagulants that contraindicate injection
  • Known allergy to dextrose or injection components
  • Pregnancy or other medical conditions preventing participation

AI-Screening

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Trial Site Locations

Total: 1 location

1

Taichung Veterans Genetal Hospital

Taichung, Taiwan, Taiwan, 407

Actively Recruiting

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Research Team

Y

Yuchun Lee, M.D.

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

TREATMENT

Number of Arms

1

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