Comparing Disease-Free Survival and Quality of Life After Modified Radical Mastectomy or Expanded Mckissock Surgery for Extensive Intraductal Breast Carcinoma

What this Trial Is About

Extensive intraductal carcinoma of the breast is a type of breast cancer where 25% or more of ductal carcinoma in situ DCIS is present within invasive tumors, often scattered around the invasive cancer. Patients with this condition are less responsive to radiotherapy and face higher risks of tumor recurrence after breast-conserving surgery compared to those without extensive DCIS. This study evaluates the postoperative disease-free survival and quality of life in patients undergoing two surgical treatments for this type of breast cancer modified radical mastectomy and expanded Mckissock surgery. The trial compares two surgical approaches. The expanded Mckissock surgery involves preserving the nipple-areola complex while removing the total gland, reshaping the breast using vertical subcutaneous pedicle flaps, and placing drainage tubes. This technique is applied based on imaging results and patient preferences. The modified radical mastectomy removes the breast tissue more extensively but also reshapes the breast with similar flap techniques and drainage. One hundred patients will be assigned to each group for comparison. Participants will be followed for five years to assess disease-free survival and quality of life using a breast cancer-specific questionnaire. Additional measurements include breast symmetry and medical costs during hospitalization. Assessments and monitoring occur throughout the follow-up period to evaluate the surgical outcomes and patient well-being after treatment. The study provides insight into the effectiveness and impact of these two surgical options for extensive intraductal carcinoma of the breast.

DFS and QOL After Modified Radical Mastectomy vs. Expanded Mckissock Surgery for EIC of the Breast