Actively Recruiting
Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease
Led by Duk-Woo Park, MD · Updated on 2025-12-30
1500
Participants Needed
27
Research Sites
180 weeks
Total Duration
On this page
Sponsors
D
Duk-Woo Park, MD
Lead Sponsor
C
CardioVascular Research Foundation, Korea
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this randomized study was to compare outcomes of imaging-and physiology-guided state-of-the-art percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) in patients with diabetes and three-vessel CAD (not involving left main).
CONDITIONS
Official Title
Diabetes-Centered Evaluation of Revascularization Strategy of Functional and Imaging-CombiNEd State-of-the-Art Percutaneous Coronary Intervention or Coronary-Artery Bypass Grafting in Patients With Diabetes Mellitus and Multivessel Coronary Artery Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 20 years of age or older with angina or evidence of myocardial ischemia
- Diagnosis of type 2 diabetes requiring insulin or oral hypoglycemic drugs, or confirmed elevated blood glucose levels
- Significant three-vessel coronary artery disease with at least 50% narrowing in each of three major vessels, excluding the left main artery
- Suitable for either PCI or CABG as determined by the Heart Team
- Ability and willingness to provide informed written consent and follow the study protocol and follow-up schedule
You will not qualify if you...
- Presence of unprotected left main coronary artery disease
- Complex coronary anatomy or conditions making PCI unsuitable
- Recent ST-elevation myocardial infarction within 5 days before randomization
- Cardiogenic shock or need for mechanical or pharmacologic hemodynamic support
- Severe left ventricular dysfunction with ejection fraction below 30%
- Requirement for other cardiac or non-cardiac surgery besides allowed procedures
- Inability or contraindication to take aspirin or P2Y12 inhibitors for at least 6 months
- Previous coronary artery bypass graft surgery
- Extremely calcified or tortuous vessels preventing imaging or physiology assessment
- More than one major vessel chronically occluded (except one chronic total occlusion allowed)
- Requirement or potential need for additional surgery within 1 year
- End-stage renal disease requiring dialysis
- Liver cirrhosis
- Pregnancy or lactation
- Medical conditions limiting life expectancy to less than 2 years
- Participation in another investigational drug or device study without completed primary endpoint follow-up, except certain observational or academic trials as allowed by the investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 27 locations
1
Palo Alto VA Medical Center
Palo Alto, California, United States, 94304
Not Yet Recruiting
2
Fuwai Hospital, Chinese Academy of Medical Sciences (CAMS)
Beijing, China
Not Yet Recruiting
3
Second Affiliated Hospital of Zhejiang University School of Medicine
Hanzhou, China
Actively Recruiting
4
Medanta - The Medicity
Gurugram, India
Actively Recruiting
5
Fortis Escorts Heart Institute
New Delhi, India
Not Yet Recruiting
6
Sarawak Heart Centre
Kota Samarahan, Malaysia
Actively Recruiting
7
University Clinical Center of Serbia
Belgrade, Serbia
Not Yet Recruiting
8
National Heart Centre Singapore (NHCS)
Singapore, Singapore
Not Yet Recruiting
9
Daegu Catholic University Medical Center
Daegu, South Korea
Not Yet Recruiting
10
Keimyung University Dongsan Medical Center
Daegu, South Korea
Actively Recruiting
11
Yeungnam University Medical Center
Daegu, South Korea
Not Yet Recruiting
12
Chungnam National University Hospital
Daejeon, South Korea
Not Yet Recruiting
13
Konyang University Hospital
Daejeon, South Korea
Withdrawn
14
Gangneung Asan Hospital
Gangneung, South Korea
Not Yet Recruiting
15
Chonnam National University Hospital
Gwangju, South Korea
Actively Recruiting
16
National Health Insurance Service Ilsan Hospital
Ilsan, South Korea
Actively Recruiting
17
Gachon University Gil Hospital
Incheon, South Korea
Not Yet Recruiting
18
Dong-A Medical Center
Pusan, South Korea
Actively Recruiting
19
Asan Medical Center
Seoul, South Korea
Actively Recruiting
20
Hanyang University Seoul Hospital
Seoul, South Korea
Not Yet Recruiting
21
Samsung Medical Center
Seoul, South Korea
Actively Recruiting
22
SNU Boramae Medical Center
Seoul, South Korea
Not Yet Recruiting
23
The Catholic University of Korea, St. Vincent's Hospital
Suwon, South Korea
Not Yet Recruiting
24
The Catholic University of Korea, Uijeongbu ST. Mary's Hospital
Uijeongbu-si, South Korea
Actively Recruiting
25
Ulsan University Hospital
Ulsan, South Korea
Actively Recruiting
26
National Taiwan University Hospital
Taipei, Taiwan
Not Yet Recruiting
27
Siriraj Hospital
Bangkok, Thailand
Actively Recruiting
Research Team
J
Jung-hee Ham, Project manager
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here