Actively Recruiting
Diabetes RElated to Acute Pancreatitis and Its Mechanisms (DREAM) Observational Cohort Study From the Type 1 Diabetes in Acute Pancreatitis Consortium
Led by Milton S. Hershey Medical Center · Updated on 2025-11-18
800
Participants Needed
13
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Milton S. Hershey Medical Center
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating how diabetes develops after an episode of acute pancreatitis (AP) through a 36-month observational study called DREAM. The study aims to understand the frequency, causes, and biological changes involved in diabetes following AP, including the possible ongoing damage to insulin-producing cells and immune system changes that may increase diabetes risk. Participants undergo several metabolic tests such as oral glucose tolerance testing, mixed meal tolerance testing, and frequently sampled intravenous glucose tolerance testing to detect diabetes early and assess pancreatic function. These tests, performed at multiple time points, help study hormone responses and insulin secretion related to diabetes development after AP. During the study, participants will be followed for three years with regular assessments including metabolic tests and questionnaires about health, pain, physical function, anxiety, depression, fatigue, sleep, social participation, and immune markers. Researchers will monitor the onset of diabetes, pancreatic function, and autoimmune changes to better understand diabetes linked to acute pancreatitis.
CONDITIONS
Brief Title
Diabetes RElated to Acute Pancreatitis and Its Mechanisms
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of acute pancreatitis within 0 to 90 days before enrollment
- Ability to fully participate in the study including informed consent, completing forms, interviews, metabolic tests, and follow-ups
- Age between 18 and 75 years
You will not qualify if you...
- Definite chronic pancreatitis diagnosed by imaging before enrollment
- Post-endoscopic retrograde cholangiopancreatography acute pancreatitis with hospitalization less than 48 hours
- Prior pancreatic necrosectomy or drainage before enrollment
- Pancreatic tumors or cystic tumors causing acute pancreatitis
- Prior pancreatic surgery such as distal pancreatectomy or pancreaticoduodenectomy
- Use of disallowed medications within 30 days before enrollment
- Severe systemic illnesses like organ transplant, AIDS, recent cancer treatment, advanced kidney disease, or cirrhosis
- Known pregnancy at enrollment
- Incarceration
- Any condition that would risk safety or affect study integrity
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 3 months
Participants undergo dynamic metabolic testing including oral glucose tolerance testing (OGTT), mixed meal tolerance testing (MMTT), and frequently sampled intravenous glucose tolerance testing (FSIGTT) to assess diabetes diagnosis and pancreatic function.
Visits at months 3, 12, 24, and 36 with additional FSIGTT testing at months 3 and 12
Duration - 36 months
Participants are followed over 36 months to monitor the development of diabetes and related metabolic changes after acute pancreatitis.
Follow-up visits at months 3, 12, 24, and 36 for assessments including PROMIS health questionnaires, islet autoantibodies, and fecal elastase
Trial Site Locations
Total: 13 locations
1
University of Southern California
Los Angeles, California, United States, 90033
Actively Recruiting
2
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
3
Stanford University
Stanford, California, United States, 94305
Actively Recruiting
4
University of Florida
Gainesville, Florida, United States, 32610-0214
Actively Recruiting
5
AdventHealth
Orlando, Florida, United States, 32804
Actively Recruiting
6
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
7
University of Illinois at Chicago
Chicago, Illinois, United States, 60612
Actively Recruiting
8
Indiana University
Indianapolis, Indiana, United States, 46202
Actively Recruiting
9
Johns Hopkins University
Baltimore, Maryland, United States, 21205
Actively Recruiting
10
University of Minnesota
Minneapolis, Minnesota, United States, 55454
Actively Recruiting
11
Ohio State University
Columbus, Ohio, United States, 43210
Actively Recruiting
12
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
Actively Recruiting
13
Benaroya Research Institute
Seattle, Washington, United States, 98101
Actively Recruiting
Research Team
M
Melissa A Butt, DrPH
K
Kendall T Baab, BS
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here