Study of Diabetes Development After Acute Pancreatitis and Its Underlying Mechanisms Over 3 Years

What this Trial Is About

Researchers are investigating how diabetes develops after an episode of acute pancreatitis AP through a 36-month observational study called DREAM. The study aims to understand the frequency, causes, and biological changes involved in diabetes following AP, including the possible ongoing damage to insulin-producing cells and immune system changes that may increase diabetes risk. Participants undergo several metabolic tests such as oral glucose tolerance testing, mixed meal tolerance testing, and frequently sampled intravenous glucose tolerance testing to detect diabetes early and assess pancreatic function. These tests, performed at multiple time points, help study hormone responses and insulin secretion related to diabetes development after AP. During the study, participants will be followed for three years with regular assessments including metabolic tests and questionnaires about health, pain, physical function, anxiety, depression, fatigue, sleep, social participation, and immune markers. Researchers will monitor the onset of diabetes, pancreatic function, and autoimmune changes to better understand diabetes linked to acute pancreatitis.

Diabetes RElated to Acute Pancreatitis and Its Mechanisms