Observational Study to Detect Variable Aldosterone Production in Primary Aldosteronism Using 24-Hour Urine and Blood Tests

What this Trial Is About

This observational study focuses on people with Primary Aldosteronism, a condition linked to high blood pressure. Researchers aim to discover if measuring aldosterone over 24 hours in urine can identify more cases and if aldosterone production shows a daily pattern or cycles. The study seeks to better understand variations in aldosterone secretion that might affect diagnosis. Participants will provide a 24-hour urine sample to measure aldosterone levels. Additionally, multiple blood tests will be taken throughout the day to observe changes in aldosterone secretion. The study does not involve treatment but monitors hormone levels to evaluate diagnostic methods. During the study, participants will undergo scheduled urine collection and blood sampling for analysis. Researchers will measure the sensitivity and specificity of 24-hour urine aldosterone excretion and study differences between day and night hormone levels. They will also assess clinical and biochemical outcomes for patients who qualify for adrenalectomy. The total study duration for outcomes is 12 months.

Diagnosing Variable Primary Aldosteronism.