Actively Recruiting
Diagnosis of Graft Pathology by TruGraf
Led by University Health Network, Toronto · Updated on 2024-08-16
471
Participants Needed
1
Research Sites
179 weeks
Total Duration
On this page
Sponsors
U
University Health Network, Toronto
Lead Sponsor
T
Transplant Genomics, Inc.
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to to identify different causes of liver diseases or damage in liver transplant patients and develop a machine learning algorithm as a non-invasive tool leveraging gene expression and patient clinical information to classify transplant liver diseases We will collect blood samples of the participants who had undergone or will undergo the liver biopsy as part of standard of care, and use this blood in TruGarf. TruGraf is a non-invasive test that measures differentially expressed genes in the blood of transplant recipients to rule out liver damage. Researcher will collect the biopsy result from the medical record and this will be compared with the TruGarf results.
CONDITIONS
Official Title
Diagnosis of Graft Pathology by TruGraf
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Single-organ liver transplant recipients
- Male or female, age over 18 years at the time of signing informed consent
- Willing and able to provide informed consent
- Patients undergoing liver graft biopsy or who have had a biopsy within 48 hours of consent
You will not qualify if you...
- Repeat liver transplant recipients
- Recipients of multi-organ transplantation
- Patients who have received IV steroid treatment for graft rejection before biopsy
- Patients with targeted biopsies for diagnosis of malignancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Toronto General Hospital -UHN
Toronto, Ontario, Canada, M5G 2N2
Actively Recruiting
Research Team
S
Sameera Rizvi
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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