Actively Recruiting
Diagnosis of Lymphohistiocytic Hemophagocytosis in Intensive Care
Led by University Hospital, Strasbourg, France · Updated on 2026-01-15
100
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Patients with hepatocellular insufficiency and/or cirrhosis are at risk of developing invasive fungal infections, particularly in critical care settings. In international recommendations, voriconazole is positioned as the first-line treatment for invasive aspergillosis. However, this molecule-and the azole class of antifungals-is associated with frequent hepatic toxicity. Available since 2018, isavuconazole appears to be better tolerated in patients without pre-existing liver dysfunction. The aim of this study is to retrospectively evaluate the validity of the hscore in intensive care and resuscitation patients.
CONDITIONS
Official Title
Diagnosis of Lymphohistiocytic Hemophagocytosis in Intensive Care
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patient (≥18 years old)
- Patient admitted to the intensive care unit at Hautepierre Hospital, Strasbourg University Hospital, between January 1, 2014, and December 31, 2024
- At least 3 biological signs of HLH:
- ferritin > 2000 ng/mL
- triglycerides > 1.5 g/L
- at least one cytopenia (leukocytes ≤ 5000 G/L, platelets ≤ 110 G/L, hemoglobin ≤ 9.2 g/dL)
You will not qualify if you...
- Refusal to participate in the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Médecine intensive - Réanimation - CHU de Strasbourg - France
Strasbourg, France, 67091
Actively Recruiting
Research Team
A
Antonin HUGEROT, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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