Use of an Integrated Mathematical Model for the Diagnosis, Treatment, and Outcome Assessment of Septic Cardiomyopathy

What this Trial Is About

Researchers are evaluating whether a new integrated mathematical model can improve the accuracy of diagnosing septic cardiomyopathy and predicting clinical outcomes in adults with suspected septic cardiomyopathy. This multicenter, prospective observational study focuses on patients treated for sepsis or septic shock in intensive care units. The aim is to see if combining clinical and echocardiographic data into one cardiovascular estimate enhances diagnosis and outcome prediction compared to the standard method. Adult patients meeting specific sepsis and septic shock criteria will undergo a primary transthoracic echocardiography within 48 hours of enrollment, alongside hemodynamic measurements. A second echocardiography will be performed within 10 days during ongoing ICU care or hospital ward stay, depending on patient progress. Data from both evaluations will be used in the integrated model to assess its diagnostic and predictive value. After hospital discharge, participants will be followed for up to one year, including completing a quality of life questionnaire (SF-36). Researchers will monitor overall health, functional status, healthcare visits, and nursing care needs to understand the long-term effects of septic cardiomyopathy. The study's main outcome is comparing the incidence of septic cardiomyopathy diagnosed by the new model versus the standard left ventricular ejection fraction method over this period.

Diagnosis, Treatment, and Outcome Assessment of Septic Cardiomyopathy Using an Integrated Mathematical Model