Actively Recruiting

All Genders
NCT06445088

Diagnostic Accuracy of EBV C Promoter Methylation Kit in Nasopharyngeal Carcinoma

Led by Sun Yat-sen University · Updated on 2024-06-25

908

Participants Needed

5

Research Sites

135 weeks

Total Duration

On this page

Sponsors

S

Sun Yat-sen University

Lead Sponsor

F

Fujian Cancer Hospital

Collaborating Sponsor

AI-Summary

What this Trial Is About

This clinical study aims to evaluate the diagnostic performance of a new Epstein-Barr virus (EBV) C promoter methylation detection kit. All participants will undergo a series of diagnostic tests including VCA-IgA, EBNA1-IgA, and EBV-DNA assays. Additionally, nasopharyngeal swabs will be analyzed for EBV C promoter methylation. Confirmatory biopsy will be performed on all patients to establish a definitive diagnosis. This comprehensive approach seeks to assess the effectiveness of the methylation detection kit in a clinical setting.

CONDITIONS

Official Title

Diagnostic Accuracy of EBV C Promoter Methylation Kit in Nasopharyngeal Carcinoma

Who Can Participate

All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Understand, sign, and date the informed consent document to participate in the study
  • Display one or more symptoms or signs indicative of nasopharyngeal carcinoma
  • Test positive for EBV antibodies or EBV DNA
  • Be diagnosed with other head and neck carcinomas
  • Be diagnosed with malignancies associated with EBV infection
  • Require differential diagnosis from nasopharyngeal carcinoma during endoscopic or other imaging examinations
  • Fulfill any additional conditions deemed appropriate by the investigator for inclusion in this study
Not Eligible

You will not qualify if you...

  • Have been diagnosed with nasopharyngeal carcinoma and have undergone treatment
  • Experience relapse or metastasis of nasopharyngeal carcinoma following treatment
  • Have unsuccessful nasopharyngeal swab collections
  • Present any other conditions considered by the investigator as unsuitable for participation in this trial

AI-Screening

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Trial Site Locations

Total: 5 locations

1

Fujian Cancer Hospital

Fuzhou, Fujian, China, 350014

Actively Recruiting

2

Sun Yat-Sen University Cancer Center

Guangzhou, Guangdong, China, 510060

Actively Recruiting

3

ZhongShan City People's Hospital

Zhongshan, Guangdong, China, 528400

Actively Recruiting

4

The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, China, 530021

Actively Recruiting

5

Wuzhou Red Cross Hospital

Wuzhou, Guangxi, China, 543002

Actively Recruiting

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Research Team

H

Hai-Qiang Mai

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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