Actively Recruiting
Diagnostic Accuracy of Folate-Targeted NIR-II Carbon Dots for Ex Vivo HCC Detection
Led by West China Hospital · Updated on 2025-12-19
20
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective, single-center observational study evaluates the diagnostic accuracy of a novel Folate-targeted Near-Infrared II Carbon Dot (FA-CDots) probe for the ex vivo assessment of Hepatocellular Carcinoma (HCC). Following standard radical hepatectomy, resected liver specimens will be incubated with the FA-CDots probe and imaged using a NIR-II fluorescence system. The study aims to determine the feasibility and accuracy of this technology in identifying tumor margins and micro-lesions by comparing the fluorescence imaging results with standard histopathological examination.
CONDITIONS
Official Title
Diagnostic Accuracy of Folate-Targeted NIR-II Carbon Dots for Ex Vivo HCC Detection
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary diagnosis of Hepatocellular Carcinoma (HCC) confirmed clinically or by preoperative biopsy
- Scheduled for radical hepatectomy
- Preoperative imaging (CT/MRI) shows indistinct tumor boundaries, infiltrative growth, or tumor close to major vessels with expected margin less than 1 cm
- Liver function classified as Child-Pugh Grade A
- ASA Physical Status classification I-III
- Participant or legal guardian willing to sign informed consent for use of ex vivo tissues
You will not qualify if you...
- Presence of other malignant tumors
- Severe dysfunction of heart, lung, kidney, or brain that prevents tolerating surgery
- Recurrent Hepatocellular Carcinoma
- Preoperative evidence of cancer spread outside liver or major blood vessel invasion
- Received anti-tumor treatment before surgery
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
West China Hospital
Chengdu, Sichuan, China, 610041
Actively Recruiting
Research Team
J
Jiwei Huang Professor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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