Actively Recruiting
Diagnostic Accuracy of Oral Images, OPGs, Biomarkers and Questionnaires vs. Clinical Assessment for Periodontal Disease (PostNCT07164573)
Led by Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · Updated on 2026-04-30
2000
Participants Needed
3
Research Sites
156 weeks
Total Duration
On this page
Sponsors
S
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Lead Sponsor
U
University of Chieti
Collaborating Sponsor
AI-Summary
What this Trial Is About
This multi-center, cross-sectional diagnostic trial evaluates the accuracy of multiple non-invasive screening tools-including self-reported questionnaires, intra-oral photographs, orthopantomographs (OPGs), intraoral scans (IOS), and salivary/microbial biomarkers-for detecting periodontal health and diseases (gingivitis and periodontitis Stages I-IV), using full-mouth clinical periodontal examination as the reference standard. A total of 2,000 participants will be recruited across five international centers. Diagnostic performance (sensitivity, specificity, AUROC) of individual and combined methods will be assessed using logistic regression and machine learning algorithms to establish an optimized multi-modal screening algorithm.
CONDITIONS
Official Title
Diagnostic Accuracy of Oral Images, OPGs, Biomarkers and Questionnaires vs. Clinical Assessment for Periodontal Disease (PostNCT07164573)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged 18 years or older
- Seeking dental care at one of the participating study centers
- Ability to understand and willingness to provide written informed consent
You will not qualify if you...
- Edentulous patients (complete tooth loss)
- Pregnancy or lactation
- History of periodontal therapy (other than supragingival prophylaxis/cleaning) within the past 12 months
- Use of antibiotic medication within the 3 months prior to enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 200000
Actively Recruiting
2
Department of Oral and Maxillofacial Sciences, Policlinico Umberto I, affiliated to Sapienza University
Roma, Roma, Italy, 06100
Not Yet Recruiting
3
Department of Periodontology, Guy's Hospital affiliated to King's College London
London, United Kingdom
Not Yet Recruiting
Research Team
M
Maurizio S. Tonetti
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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