Actively Recruiting
Diagnostic of D-lactate in Cerebrospinal Fluid Level in Patients With Suspected Ventriculostomy-related Meningitis
Led by University Hospital, Toulouse · Updated on 2025-12-31
185
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The TOTEM study is a single-center study designed to evaluate the performance of the D-lactate assay in cerebrospinal fluid (CSF) for the diagnosis of ventriculostomy-related nosocomial meningitis. The study will be conducted in the neurosurgical intensive care unit of the Toulouse University Hospital, in patients with a suspected diagnosis of ventriculostomy-related nosocomial meningitis.
CONDITIONS
Official Title
Diagnostic of D-lactate in Cerebrospinal Fluid Level in Patients With Suspected Ventriculostomy-related Meningitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years.
- Patient with an external ventriculostomy implanted at the Toulouse University Hospital.
- Patient suspected of nosocomial meningitis due to a febrile syndrome (in the absence of any other identified infectious site), headache, nausea, lethargy, change in neurological status, meningeal syndrome, epileptic event and cutaneous or subcutaneous inflammation at the ventriculostomy site of insertion.
- Patient having expressed oral consent, after free and informed information.
- Patient affiliated to a social security scheme.
You will not qualify if you...
- Diagnosis of community meningitis.
- Proven or suspected meningitis and/or ventriculitis during the previous month.
- Diagnosis of nosocomial meningitis made in another medical centre prior to admission.
- Short bowel syndrome.
- Acute mesenteric ischaemia.
- End-stage renal failure (GFR < 15 ml/min/m2).
- Peritoneal dialysis.
- Patient participating in another research protocol with an exclusion period still in progress.
- Pregnant or breastfeeding woman.
- Patient under guardianship or trusteeship, persons placed under the protection of justice
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Toulouse Hospital
Toulouse, France
Actively Recruiting
Research Team
L
Lucie LELIEVRE, Md
CONTACT
G
Guillaume MARTIN-BLONDEL, Md
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here