Actively Recruiting
Diagnostic Evaluation of Dementia with Lewy Bodies Using a Multimodal Approach
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2025-03-27
130
Participants Needed
1
Research Sites
155 weeks
Total Duration
On this page
Sponsors
A
Assistance Publique - Hôpitaux de Paris
Lead Sponsor
A
Association des Aidants et Malades à Corps de Lewy (A2MCL)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Dementia with Lewy body disease (DLB) is the second leading cause of degenerative cognitive disorder after Alzheimer's disease (AD). Its variable clinical expression makes diagnosis difficult. To date, there is no validated DLB diagnostic biomarker, despite several biomarkers in development (EEG, MRI, biology). Studies have shown that an improvement in diagnostic performance could be obtained by combining different modalities biomarkers using machine learning. The aim of this research is to identify the best combination of multimodal biomarkers for the diagnosis of DLB (EEG, MRI, biology, cognitive scores), using a machine learning approach applied to a clinical cohort.
CONDITIONS
Official Title
Diagnostic Evaluation of Dementia with Lewy Bodies Using a Multimodal Approach
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to complete a neuropsychological assessment in French without significant visual or hearing impairment
- Diagnosis of dementia with Lewy bodies following revised McKeith 2017 criteria or probable Alzheimer's disease according to McKhann 2011 criteria including CSF biomarkers
- For control participants: MMSE score of 28 or higher, normal MemScreen test, normal brain MRI, and normal neurological exam
- Age between 55 and 85 years
You will not qualify if you...
- Contraindication to MRI
- Presence of other neurological, psychiatric, toxic, or iatrogenic disorders that explain cognitive impairment or EEG abnormalities
- Unstable medical conditions that may cause cognitive impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre de neurologie Cognitive
Paris, France, France, 75010
Actively Recruiting
Research Team
C
Claire PAQUET, MDPhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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