Actively Recruiting
Diagnostic Feasibility of 100 Hz Tetanic Stimulation in the Perioperative Setting in Patients With Normal and Abnormal ENG: a Pilot Study
Led by University of Debrecen · Updated on 2025-03-27
40
Participants Needed
2
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the use of 100 Hz tetanic stimulation with an electromyography (EMG) device to study postoperative residual neuromuscular block in anaesthetized patients. The study aims to find out if fatigue develops with this stimulation in patients who have either normal or abnormal baseline electroneurographic (ENG) findings. This research also explores how chronic conditions affecting peripheral nerves, like polyneuropathy, may impact the test's usefulness. During the study, the ulnar nerve at the carpal tunnel is stimulated supramaximally, and the electric response of the abductor digiti minimi muscle is recorded using the Alpine Biomed ENG-EMG device with Keypoint software. Patients are grouped based on their initial ENG results into normal or abnormal ENG groups. Tetanic stimulation at frequencies of 60 and 100 Hz is applied for 5 seconds to assess responses. Participants undergo ENG testing after anesthesia induction, with monitoring lasting up to one hour during anesthesia. No further ENG measurements occur postoperatively. The study evaluates the 100 Hz tetanic fade response and the diagnostic feasibility of EMG in assessing the neuromuscular safety margin. Participants' arms are positioned and prepared for electrode placement following standard procedures.
CONDITIONS
Brief Title
Diagnostic Feasibility of 100 Hz Tetanic Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA physical status classification 1 to 3
- Body mass index between 18.5 and 25 (normal body weight)
- Patient is lying on their back (supine position) with one arm accessible for testing
You will not qualify if you...
- Diseases that impair neuromuscular function such as myopathies or severe liver and kidney failure
- Use of drugs that affect neuromuscular function including magnesium and aminoglycosides
- Pregnancy (pregnancy tests done for women of childbearing age)
- Breastfeeding
- Undergoing acute surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 1 hour during anesthesia
Participants undergo electromyography (EMG) and electroneurography (ENG) testing during anesthesia to assess neuromuscular function using 100 Hz tetanic stimulation.
1 in-person assessment during anesthesia
Trial Site Locations
Total: 2 locations
1
Department of Anesthesiology and Intensive Care, University of Debrecen
Debrecen, Hajdú-Bihar, Hungary, 4032
Not Yet Recruiting
2
University of Debrecen Medical Center, Department of Anesthesiology and Intensive Care
Debrecen, Hungary, 4032
Actively Recruiting
Research Team
A
Adrienn Pongrácz, MD PhD
R
Réka Nemes, MD PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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