Actively Recruiting

Age: 18Years +
All Genders
Healthy Volunteers
ID00221897

Diagnostic Innovations in Glaucoma Study Evaluation of Glaucoma and Myopia Impact on Visual Function and Optic Nerve Structure

Led by University of California, San Diego · Updated on 2025-10-24

3000

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

Sponsors

U

University of California, San Diego

Lead Sponsor

N

National Eye Institute (NEI)

Collaborating Sponsor

AI-Summary

What this Trial Is About

Researchers are studying changes in visual function and the structure of the optic nerve in people with glaucoma or those at increased risk of developing glaucoma. The goal is to find the best ways to detect glaucoma or its worsening over time, especially in people with myopia and in different ethnic groups. The study also aims to understand how glaucoma affects daily life and vision quality, and to distinguish glaucoma progression from normal age-related changes. Participants include healthy individuals, those suspected of having glaucoma, and glaucoma patients, with or without myopia. They are examined about twice a year with various tests such as visual acuity, eye pressure measurements, imaging scans, and color vision testing. There is also an optional additional study involving imaging and pressure measurements in different body positions. Some glaucoma patients may temporarily stop eye pressure medication before imaging under medical supervision. Participants typically attend 2 to 4 visits per year, each lasting 2 to 5 hours, for several years as long as funding continues. Tests include eye exams, imaging, blood pressure, and vision function assessments. Researchers monitor changes in glaucoma status over time and compare results with healthy controls. The study involves multiple centers and collects detailed data to improve glaucoma diagnosis and management.

CONDITIONS

Brief Title

Diagnostic Innovations in Glaucoma Study

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Healthy controls with or without myopia, and patients with or without myopia diagnosed with glaucoma, glaucoma suspect, or ocular hypertension
  • Age 18 years or older
  • No upper age limit
  • No restriction by gender, race, or ethnicity
Not Eligible

You will not qualify if you...

  • Participants with other eye or systemic conditions or treatments that may affect visual function are excluded

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Ongoing with no fixed end date

Participants undergo extensive eye examinations and tests including visual acuity, intraocular pressure measurements, imaging, and other diagnostic assessments to evaluate glaucoma and myopia impact on visual function and optic nerve structure.

2 to 4 visits per year, each lasting approximately 2 to 5 hours

Long-term Monitoring

Duration - Ongoing with no fixed end date

Participants are monitored longitudinally with biannual examinations to track changes in eye health and visual function over time.

Approximately 2 visits per year

Trial Site Locations

Total: 1 location

1

UCSD, Hamilton Glaucoma Center

La Jolla, California, United States, 92093-0946

Actively Recruiting

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Research Team

V

Veronica Inpirom

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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Published Research Related To This Trial

Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography.

Felipe A Medeiros, Linda M Zangwill, Christopher Bowd...

https://pubmed.ncbi.nlm.nih.gov/15652827

Heidelberg retina tomograph measurements of the optic disc and parapapillary retina for detecting glaucoma analyzed by machine learning classifiers.

Linda M Zangwill, Kwokleung Chan, Christopher Bowd...

https://pubmed.ncbi.nlm.nih.gov/15326133

Confocal scanning laser ophthalmoscopy classifiers and stereophotograph evaluation for prediction of visual field abnormalities in glaucoma-suspect eyes.

Christopher Bowd, Linda M Zangwill, Felipe A Medeiros...

https://pubmed.ncbi.nlm.nih.gov/15223803

Using unsupervised learning with variational bayesian mixture of factor analysis to identify patterns of glaucomatous visual field defects.

Pamela A Sample, Kwokleung Chan, Catherine Boden...

https://pubmed.ncbi.nlm.nih.gov/15277482

Comparison of the GDx VCC scanning laser polarimeter, HRT II confocal scanning laser ophthalmoscope, and stratus OCT optical coherence tomograph for the detection of glaucoma.

Felipe A Medeiros, Linda M Zangwill, Christopher Bowd...

https://pubmed.ncbi.nlm.nih.gov/15197057