Actively Recruiting

Age: 18Years +
All Genders
NCT05888974

Diagnostic Performance of the Mitral Annulus Velocity Variation Measured by Tissue Doppler to Evaluate the Fluid Responsiveness During the Initial Management of Shock in Patients Admitted to the Emergency Department

Led by Centre Hospitalier Universitaire de Nīmes · Updated on 2025-12-04

187

Participants Needed

1

Research Sites

178 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Assessing the response to vascular filling in shock is a challenge in emergency medicine. The mitral annulus velocity measured by tissue Doppler (E') has recently been characterized as sensitive to the preload conditions of a patient. The investigators hypothesize that the E' variation (∆E') before and after fluid filling allows us to assess the response to vascular filling. The investigators hypothesize that the ∆E' has a good diagnostic performance to establish whether a patient is responsive to fluid filling, defined by an area under the ROC curve greater than 0.75.

CONDITIONS

Official Title

Diagnostic Performance of the Mitral Annulus Velocity Variation Measured by Tissue Doppler to Evaluate the Fluid Responsiveness During the Initial Management of Shock in Patients Admitted to the Emergency Department

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patient has been informed of the study and does not refuse to participate.
  • Patient is at least 2618 years of age.
  • The patient must be beneficiary of a health insurance plan.
  • Patient has shock with a mean blood pressure less than 65 mmHg (<).
  • The patient does not have acute intracranial pathology.
  • The referring physician has decided on a vascular filling with 500mL of crystalloids (NaCl 0.9% or Ringer lactate).
Not Eligible

You will not qualify if you...

  • The patient has already received 2 vascular fillings since the beginning of his management.
  • The patient is in shock and has a contraindication to vascular filling: shock of a cardiogenic or obstructive nature.
  • The patient has an intracranial pathology requiring maintain a MAP 2680 mmHg.
  • The patient is intubated or on Non-Invasive Ventilation before the vascular filling.
  • The patient is under court protection.
  • The patient is pregnant, parturient or nursing.

AI-Screening

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Trial Site Locations

Total: 1 location

1

CHU de Nîmes

Nîmes, France, 34000

Actively Recruiting

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Research Team

L

Laura GRAU MERCIER, MD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

1

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