Actively Recruiting
Diagnostic Performance of Mitral Annulus Velocity Variation by Tissue Doppler to Evaluate Fluid Responsiveness During Initial Shock Management in Emergency Department
Led by Centre Hospitalier Universitaire de Nīmes · Updated on 2025-12-04
187
Participants Needed
1
Research Sites
20 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the use of mitral annulus velocity variation (E') measured by tissue Doppler ultrasound as a diagnostic tool to evaluate fluid responsiveness in patients admitted to the emergency department with shock. Shock is characterized by low blood pressure requiring vascular filling, and assessing how patients respond to fluid filling is a critical challenge in emergency medicine. This observational study aims to determine if changes in E' before and after fluid filling can accurately identify patients who benefit from such treatment. During the study, patients with shock and mean arterial pressure below 65 mmHg who require vascular filling will undergo three cardiac ultrasounds. The first ultrasound occurs at the start of a 500 mL fluid infusion, the second immediately after the infusion ends, and the third 20 minutes later. These ultrasounds are part of standard care and are used to monitor heart function and fluid response. The study focuses on measuring the change in E' velocity around the time of fluid administration. Participants will be monitored through these ultrasound assessments during their initial management in the emergency department. The main outcomes measured are the variation in E' velocity and fluid filling responsiveness at the time of inclusion. Additional monitoring includes a later E' measurement. The study seeks to improve diagnostic methods for fluid responsiveness in emergency care, with participation lasting during the initial emergency treatment period.
CONDITIONS
Brief Title
Diagnostic Performance of the Mitral Annulus Velocity Variation Measured by Tissue Doppler to Evaluate the Fluid Responsiveness During the Initial Management of Shock in Patients Admitted to the Emergency Department
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient has been informed of the study and does not refuse to participate.
- Patient is at least 18 years old.
- Patient has health insurance coverage.
- Patient has shock with mean blood pressure less than 65 mmHg.
- Referring physician has decided on vascular filling with 500 mL of crystalloids (NaCl 0.9% or Ringer lactate).
- Patient does not have acute intracranial pathology.
You will not qualify if you...
- Patient has already received two vascular fillings since treatment began.
- Patient is in shock with contraindication to vascular filling (cardiogenic or obstructive shock).
- Patient has intracranial pathology requiring mean arterial pressure of at least 80 mmHg.
- Patient is intubated or on Non-Invasive Ventilation before vascular filling.
- Patient is under court protection.
- Patient is pregnant, parturient, or nursing.
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within a few hours on the day of inclusion
Participants undergo cardiac ultrasonography to evaluate fluid responsiveness during initial shock management in the emergency department.
1 inclusion visit with 3 ultrasound assessments (at initiation of vascular filling, at end of filling, and 20 minutes after filling)
Duration - Up to study completion
Participants are observed for outcomes related to fluid responsiveness and cardiac function after initial diagnostic evaluation.
No additional specific visits; observations are based on clinical follow-up
Trial Site Locations
Total: 1 location
1
CHU de Nîmes
Nîmes, France, 34000
Actively Recruiting
Research Team
L
Laura GRAU MERCIER, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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