Study of Diagnostic and Prognostic Biomarkers in Adults with Suspected Idiopathic Intracranial Hypertension

What this Trial Is About

Idiopathic intracranial hypertension IIH is a condition that mainly affects overweight women of childbearing age, causing symptoms like headaches and vision problems due to increased pressure in the brain. Diagnosing IIH can be challenging, and outcomes vary widely from full recovery to serious issues like blindness or chronic headaches. Researchers aim to find biomarkers that can help diagnose and predict the course of IIH and to create a clinical database to better understand patient characteristics and outcomes. This study is a multicenter, prospective, population-based cohort study involving patients suspected of having IIH. Participants will undergo medical history reviews, neurological and eye exams, neuroimaging, blood tests, and lumbar punctures. They may also receive evaluations from other specialists such as neuropsychologists. Based on established criteria, patients will be grouped into those with confirmed IIH, suspected but unconfirmed IIH, or IIH ruled out. Patients receive standard care and follow-up as usual. Participants will be followed over time at headache centers and by neuro-ophthalmologists with regular assessments including visual and headache status. The study collects clinical data and biological samples to identify diagnostic and prognostic biomarkers. Researchers will analyze baseline characteristics, neuropsychological results, treatment, and follow-up data to develop standardized care programs. The total study duration includes data collection and monitoring over several years to evaluate outcomes and improve IIH management.

Diagnostic and Prognostic Biomarkers of Idiopathic Intracranial Hypertension