Urine culture contamination: a College of American Pathologists Q-Probes study of 127 laboratories.
Leonas G Bekeris, Bruce Allen Jones, Molly K Walsh...
https://pubmed.ncbi.nlm.nih.gov/18517272Actively Recruiting
Phase Not Applicable
Age: 18Years +
All Genders
ID07246837
A Randomized Controlled Trial of a Diagnostic Stewardship Intervention to Reduce Inappropriate Antibiotic Use for Urinary Tract Infections in Primary Care
Led by Baylor College of Medicine · Updated on 2026-02-13
252
Participants Needed
1
Research Sites
91 weeks
Total Duration
On this page
Sponsors
B
Baylor College of Medicine
Lead Sponsor
W
Washington University School of Medicine
Collaborating Sponsor
AI-Summary
What this Trial Is About
Urinary tract infections (UTIs) are a common reason for outpatient visits and antibiotic prescriptions in the United States. This research evaluates a bilingual educational intervention designed to reduce contamination of urine cultures and inappropriate antibiotic use in adult patients visiting safety-net primary care clinics. The study aims to improve diagnostic accuracy and support antimicrobial stewardship by providing clear and culturally appropriate instructions for urine collection. The intervention includes a short animated video and a pictorial flyer, both available in English and Spanish, which explain the proper midstream clean-catch urine (MSCC) collection technique. Participants are randomly assigned to either receive this educational tool before urine collection or to receive usual care without additional education. Men and women receive materials tailored to their needs. The trial compares contamination rates of urine cultures, antibiotic use, and contaminated urinalyses between the two groups. Participants are adults aged 18 or older who are asked to provide a urine sample during routine outpatient care. They will watch the educational video and view the flyer in the exam room before providing their sample if assigned to the intervention group. Researchers will collect data from medical records, patient surveys, and interviews to measure urine culture contamination within 48 hours, antibiotic prescriptions within seven days, and patient satisfaction. The study also assesses the acceptability and feasibility of the educational materials. Total participation includes the urine collection visit and follow-up assessments.
CONDITIONS
Brief Title
Diagnostic Stewardship Intervention to Reduce Inappropriate Antibiotic Use for Urinary Tract Infections in Primary Care
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adults (≥18 years) undergoing urine culture as part of routine outpatient care
- Able to provide informed consent
- English- and/or Spanish-speaking
You will not qualify if you...
- Presence of a urinary catheter
- Inability to read and sign the informed consent
- Unable to follow study procedures due to significant visual, auditory, physical, or cognitive impairment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Day of urine collection
Participants provide a urine sample for culture or urinalysis, following either usual care or an educational intervention with a video and flyer to improve urine collection technique.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 7 days post-collection
Participants are monitored for urine culture contamination, antibiotic use, and patient understanding and satisfaction after urine collection.
Follow-up assessments through electronic records and surveys
Trial Site Locations
Total: 1 location
1
Baylor College of Medicine
Houston, Texas, United States, 77098
Actively Recruiting
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Research Team
K
Kiara Olmeda, MS
A
Azalia Mancera
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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Published Research Related To This Trial
The Five Ds of Outpatient Antibiotic Stewardship for Urinary Tract Infections.
Melanie C Goebel, Barbara W Trautner, Larissa Grigoryan
https://pubmed.ncbi.nlm.nih.gov/34431702Prevalence and predictors of urine culture contamination in primary care: A cross-sectional study.
Michael A Hansen, Marissa Valentine-King, Roger Zoorob...
https://pubmed.ncbi.nlm.nih.gov/35914376Urinary Tract Infection.
Kalpana Gupta, Larissa Grigoryan, Barbara Trautner
https://pubmed.ncbi.nlm.nih.gov/28973215