Prevalence and predictors of urine culture contamination in primary care: A cross-sectional study.
Michael A Hansen, Marissa Valentine-King, Roger Zoorob...
https://pubmed.ncbi.nlm.nih.gov/35914376/Actively Recruiting
Led by Baylor College of Medicine · Updated on 2026-02-13
252
Participants Needed
1
Research Sites
91 weeks
Total Duration
Urinary tract infections UTIs are a common reason for outpatient visits and antibiotic prescriptions in the United States. This research evaluates a bilingual educational intervention designed to reduce contamination of urine cultures and inappropriate antibiotic use in adult patients visiting safety-net primary care clinics. The study aims to improve diagnostic accuracy and support antimicrobial stewardship by providing clear and culturally appropriate instructions for urine collection. The intervention includes a short animated video and a pictorial flyer, both available in English and Spanish, which explain the proper midstream clean-catch urine MSCC collection technique. Participants are randomly assigned to either receive this educational tool before urine collection or to receive usual care without additional education. Men and women receive materials tailored to their needs. The trial compares contamination rates of urine cultures, antibiotic use, and contaminated urinalyses between the two groups. Participants are adults aged 18 or older who are asked to provide a urine sample during routine outpatient care. They will watch the educational video and view the flyer in the exam room before providing their sample if assigned to the intervention group. Researchers will collect data from medical records, patient surveys, and interviews to measure urine culture contamination within 48 hours, antibiotic prescriptions within seven days, and patient satisfaction. The study also assesses the acceptability and feasibility of the educational materials. Total participation includes the urine collection visit and follow-up assessments.
CONDITIONS
Diagnostic Stewardship Intervention to Reduce Inappropriate Antibiotic Use for Urinary Tract Infections in Primary Care
K
Kiara Olmeda, MS
A
Azalia Mancera
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Baylor College of Medicine
Lead Sponsor
Washington University School of Medicine
Collaborating Sponsor
This table compares participation in this trial with other options available for this condition. The information is drawn from published research and the trial’s study details and is provided for educational purposes only.
| Factors | Educational Intervention (Video & Flyer) | Routine Collection Without Educational Tool | Current Practice in US Primary Care |
|---|---|---|---|
| What it is | A brief educational intervention (video and flyer) provided before urine collection, aiming to reduce specimen contamination and improve diagnostic accuracy. | Routine urine collection process with no targeted educational support. Standard clinical instructions may be provided, but no intervention is applied. | Most US outpatient sites use standard clinical instructions for urine collection, but structured, patient-directed education tools to reduce contamination are uncommon. |
| Role in trial | Randomized investigational condition aiming to improve urine specimen quality and support antibiotic stewardship. | Randomized comparator condition representing established, pre-intervention routine practice. | Primary diagnostic pathway in typical US outpatient care; represents baseline contamination management without additional educational tools. |
| Primary use | To reduce urine specimen contamination and support appropriate antibiotic use for suspected UTI. | Routine diagnostic evaluation for possible UTI; specimen processed without special patient education for collection. | Diagnosis of urinary tract infection based on urine specimen collected per typical outpatient workflow, with reliance on standard instructions rather than structured education. |
| How it is given or performed | Patients receive a short video and printed flyer (English or Spanish), immediately prior to urine collection, to instruct on proper specimen technique. | Usual clinical instructions for urine collection are provided. No systematic additional education is delivered. | Collection typically follows local instructions, often verbal or written, with no brief, structured patient-directed educational interventions used just before collection. |
| Evidence status | Ongoing clinical investigation; results not yet reported in registry or published literature. No efficacy outcomes available for this specific intervention tool at present. | Routine collection practices yield significant rates of specimen contamination, as documented in US outpatient labs; no systematic education is delivered. | Current literature documents urine culture contamination rates in outpatient care as high as 14%, with predictors linked to collection technique and lack of education. |
| Important limitations | Effectiveness and acceptability of educational intervention have not yet been confirmed. Impact on antibiotic prescribing and real-world specimen contamination awaits results. | Routine collection remains prone to significant contamination errors, often leading to diagnostic uncertainty and inappropriate antibiotic use. | Current collection practices without targeted education lead to substantial contamination rates and risk of unnecessary antibiotics, with limited guidance on improvement strategies. |
Disclaimer: This comparison is created with the help of artificial intelligence(AI) and may contain errors or missing information. It is not medical advice and does not mean one option is better or safer than another. Clinical trials are still being studied, and joining a trial is your choice. Please consult your healthcare professional before making any decisions.
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Day of urine collection
Participants provide a urine sample for culture or urinalysis, following either usual care or an educational intervention with a video and flyer to improve urine collection technique.
1 visit (in-person)
Duration - Up to 7 days post-collection
Participants are monitored for urine culture contamination, antibiotic use, and patient understanding and satisfaction after urine collection.
Follow-up assessments through electronic records and surveys
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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https://pubmed.ncbi.nlm.nih.gov/18517272/Baylor College of Medicine
Lead Sponsor
Washington University School of Medicine
Collaborating Sponsor