Actively Recruiting
Diagnostic Value of Photon-Counting CT in Subsegmental Pulmonary Embolism
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2026-05-08
696
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Pulmonary embolism (PE) is a serious and potentially life-threatening condition caused by blood clots in the lungs. A particular type, subsegmental pulmonary embolism (SSPE), involves very small branches of the pulmonary arteries. Although these clots occur in smaller vessels, their risk of recurrence and complications may be similar to larger clots. Conventional CT pulmonary angiography (CTPA) is the standard imaging test for suspected PE, but image quality can sometimes be limited by motion artifacts, poor contrast filling, or body habitus, making the detection of SSPE challenging. Photon-counting computed tomography (PCCT) is a new CT technology that provides higher image resolution, lower radiation dose, and improved visualization of small blood vessels. Early studies suggest PCCT may reduce motion artifacts and increase the accuracy of detecting SSPE compared with conventional CT. This prospective cohort study will compare PCCT with dual-source CT in patients with suspected acute PE. The study aims to determine whether PCCT improves the detection rate and image quality for SSPE, and whether it can provide more reliable diagnostic information to guide clinical care.
CONDITIONS
Official Title
Diagnostic Value of Photon-Counting CT in Subsegmental Pulmonary Embolism
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 63 18 years
- Clinical signs supporting acute pulmonary embolism such as sudden or worsening shortness of breath, unexplained low oxygen levels, chest pain, coughing blood, fainting or near fainting combined with abnormal ECG, echocardiography, or pulse oximetry
- Revised simplified Geneva score 63 3
- Written informed consent from the patient or legally authorized representative
You will not qualify if you...
- Need for anticoagulant medication for reasons other than venous thromboembolism
- Life expectancy less than three months
- Unable to undergo CT scan due to severe condition or unstable blood flow
- Allergy to contrast media, kidney failure with creatinine clearance < 30 mL/min, or ongoing long-term dialysis
- Pregnancy
- Refusal or inability to provide informed consent or complete follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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