Diagnosing Fungal Sinusitis in Adults with One-Sided Sinus Blockage or Nasal Discharge

What this Trial Is About

Mycotic sinusitis is a rare inflammatory condition affecting the paranasal sinuses, with rising cases in recent years. It includes non-invasive forms such as mycetoma and allergic mycotic sinusitis, often involving the maxillary sinus. Diagnosing this fungal sinusitis is challenging due to nonspecific symptoms like nasal obstruction and pain, and sometimes patients have no symptoms. Improving diagnosis is important as current methods rely on clinical signs, endoscopic findings, and CT scans, which have limitations in specificity. Patients with suspected mycotic sinusitis will undergo a detailed series of examinations. These include an ear, nose, and throat ENT assessment with questionnaires and endoscopic examination, a CT scan of the paranasal sinuses to evaluate sinus conditions and anatomical features, and functional endonasal endoscopic surgery FESS to clean the affected sinus and collect samples. Collected samples will be analyzed through histological, culture, and elemental examinations to identify fungal involvement. During the study, participants will have multiple assessments including clinical history, symptom questionnaires, nasal endoscopy, CT imaging, and surgery if needed. Samples taken during surgery will be examined for fungal presence and tissue changes. The study will follow participants for up to three years, monitoring CT scan changes, clinical symptoms, and laboratory results to better understand diagnostic signs of mycotic sinusitis. This comprehensive approach aims to improve detection and characterization of this condition.

Diagnostics of Mycotic Sinusitis in ENT Patients