Actively Recruiting
DIALysis With EXpanded Solute Removal
Led by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Updated on 2025-08-28
4800
Participants Needed
1
Research Sites
259 weeks
Total Duration
On this page
Sponsors
L
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lead Sponsor
S
Schulich School of Medicine and Dentistry
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the health effects of expanded hemodialysis in patients receiving hemodialysis. The main question it aims to answer is: 1\) Does expanded hemodialysis reduce the risk of death from any cause? Researchers will compare expanded hemodialysis to conventional hemodialysis (the treatment currently used for the majority of patients receiving hemodialysis) to see if expanded hemodialysis works to improve patient outcomes. Participants will continue to receive their regularly scheduled hemodialysis treatments using either a super high-flux/expanded dialysis filter or a high-flux/conventional dialysis filter. All other aspects of treatments remain the same. No additional tests or visits are required. Data will be obtained using administrative healthcare databases and medical record review (at a subset of participating locations).
CONDITIONS
Official Title
DIALysis With EXpanded Solute Removal
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 60 years or older, or age 45 to 59 years with a history of diabetes mellitus (Type 1 or Type 2)
- Receiving any form of dialysis regularly for the previous 90 days
- Currently receiving in-center hemodialysis 3 or more times per week
- Have a valid provincial or territorial health insurance card number
You will not qualify if you...
- Not appropriate for the study as judged by treating nephrologist or dialysis nurse practitioner due to any of:
- Known or expected intolerance to the Nipro Elisio HX dialyzer
- Planned to receive hemodiafiltration (HDF)
- Planned to receive nocturnal hemodialysis
- Expected to stop in-center hemodialysis in the next 3 months for reasons such as palliation, transplantation, home dialysis, recovery of kidney function, or death
- Expected severe non-adherence to prescribed dialysis frequency or duration
- A strong clinical preference for expanded hemodialysis use
- Other medical, psychosocial, or logistical reasons
- Enrolled in another clinical trial that prohibits concurrent participation or interferes with adherence to DIALEX procedures
- Previously enrolled in this trial
- Declined participation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
London Health Sciences Centre
London, Ontario, Canada, N6A 5W9
Actively Recruiting
Research Team
P
Pavel S Roshanov, MD MSc FRCPC
CONTACT
C
Central Research Coordinator
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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