Actively Recruiting

Age: 18Years - 100Years
All Genders
Healthy Volunteers
ID05906030

Diaphragm Dysfunction and Respiratory Complications in the Perioperative Setting Can Diaphragm Ultrasound Aid Prediction?

Led by Karolinska University Hospital · Updated on 2025-01-29

160

Participants Needed

2

Research Sites

52 weeks

Total Duration

On this page

Sponsors

K

Karolinska University Hospital

Lead Sponsor

K

Karolinska Institutet

Collaborating Sponsor

AI-Summary

What this Trial Is About

This research aims to find out if using diaphragm ultrasound to measure diaphragm thickening fraction, excursion, and density before and after major abdominal, pelvic, or vascular surgery can predict respiratory complications during the 30 days after surgery. Respiratory complications include pneumonia, desaturation, need for intubation, and other events. The study focuses on adults scheduled for elective or acute surgery and seeks to address the impact of diaphragm dysfunction on postoperative outcomes and recovery. Participants will undergo diaphragm ultrasound exams before surgery and multiple times after surgery in the postoperative ward. This non-invasive and painless imaging uses ultrasound transducers to measure diaphragm movement, thickness, and density. Researchers will also monitor vital signs, oxygen levels, medication, anesthesia details, and surgery data. The study consists of two parts: one with elective surgery patients and one with acute surgery patients, each observed closely for respiratory complications up to 30 days post-surgery. Throughout the study, participants will have their diaphragm assessed using ultrasound at set times before and after surgery, with vital parameters recorded in detail. Researchers will collect data on respiratory complications from medical records and correlate these with the ultrasound findings to evaluate diaphragm function's predictive value. Data security measures will protect ultrasound images and patient information. The study will analyze outcomes like pneumonia occurrence, respiratory insufficiency, and oxygen desaturation to better understand and prevent postoperative respiratory issues.

CONDITIONS

Brief Title

Diaphragm Dysfunction and Ultrasound Perioperatively

Who Can Participate

Age: 18Years - 100Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults undergoing elective or acute abdominal, pelvic, or vascular surgery
Not Eligible

You will not qualify if you...

  • Under 18 years old
  • Underlying chronic respiratory disease
  • Unable to give informed consent

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Preoperative day through 72 hours postoperative

Participants undergo diaphragm ultrasound examinations before surgery, on the operating table if possible, and several times in the postoperative unit to assess diaphragm function.

3 to 4 visits (in-person)

Long-term Monitoring

Duration - 30 days after surgery

Participants are observed for respiratory complications and vital parameters including pulse oximetry and breathing frequency up to 30 days after surgery.

Follow-up monitoring through medical records and clinical assessments

Trial Site Locations

Total: 2 locations

1

Karolinska University Hospital, Perioperative Medicine and Intensive Care

Stockholm, Stockholm County, Sweden, 17176

Actively Recruiting

2

Karolinska University Hospital

Stockholm, Sweden, 17176

Actively Recruiting

Loading map...

Research Team

J

Jessica Kåhlin, MD, PhD

E

Emma Larsson, MD, PhD

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

0

Similar Trials

Expanded Investigation of Inflammacheck to Measure Breath Hy...

Lung Cancer (Diagnosis)

Actively Recruiting

1 location

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here