Actively Recruiting
Diaphragmatic Physiology Similarity Index May Titrate HFNC Flow Setting: A Prospective Observational Study
Led by Sir Run Run Shaw Hospital · Updated on 2026-03-25
100
Participants Needed
2
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Study Objective This prospective observational study aims to investigate the role of the Diaphragmatic Physiology Similarity Index (DPSI) derived from speckle tracking ultrasound in titrating high-flow nasal cannula (HFNC) flow settings, and to evaluate its application in patients with acute respiratory failure. Primary Research Questions To characterize the features of the DPSI in healthy individuals and in patients with acute respiratory failure. To assess the behavior of the DPSI under different HFNC flow settings in patients with acute respiratory failure. Secondary Research Questions Feasibility and inter-operator reproducibility of diaphragmatic speckle tracking. Assessment of the Diaphragmatic Contraction Synchrony Index. Evaluation of End-Diaphragmatic Residual Contraction (EDRC). Additional fundamental parameters, including diaphragmatic displacement velocity and maximum displacement.
CONDITIONS
Official Title
Diaphragmatic Physiology Similarity Index May Titrate HFNC Flow Setting: A Prospective Observational Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Clear diagnosis of respiratory failure requiring respiratory support
- Expected respiratory support duration of 24 hours or more, or high-flow/non-invasive ventilation for 48 hours or more
- Voluntary participation with signed informed consent or proxy consent if participant is unable to consent
You will not qualify if you...
- Severe chest wall deformities or diaphragmatic paralysis
- End-stage disease with life expectancy less than 24 hours
- Inability to obtain speckle tracking ultrasound images due to conditions like severe subcutaneous emphysema or position limitations
- Vulnerable groups other than critically ill patients, elderly, or illiterate individuals, including those with mental disorders, cognitive impairments, or pregnancy
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Sir Run Run shaw Hospital Zhejiang University
Hangzhou, Zhejiang, China, 310000
Actively Recruiting
2
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Not Yet Recruiting
Research Team
H
Huiqing Ge
CONTACT
Y
Yiqing Xu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
6
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