What is this study trying to find out about weaning from mechanical ventilation?

This study is investigating new ways to assess diaphragm function during a spontaneous breathing trial in patients being weaned from mechanical ventilation. It aims to evaluate diaphragmatic strain and movement to help detect dysfunction earlier. The research is sponsored by Centre Hospitalier Universitaire, Amiens and focuses on improving monitoring techniques during weaning.

Who may be eligible for this weaning clinical trial?

Adults 18 years or older who have been on mechanical ventilation for at least 24 hours and meet criteria for a spontaneous breathing trial may be eligible. Participants must be able to trigger breaths with some ventilator assistance and not require significant hemodynamic support. Both sexes can participate. Please review eligibility criteria for more details.

Is there any cost to participate in this weaning clinical trial?

Study-related care, including all monitoring and assessments during the spontaneous breathing trial, is provided at no cost. Personal travel expenses may vary and are not guaranteed to be covered.

Actively Recruiting

Age: 18Years +

All Genders

ID06009731

Study of Diaphragm Movement Using Speckle Tracking During a Spontaneous Breathing Trial in Adults on Mechanical Ventilation

Led by Centre Hospitalier Universitaire, Amiens · Updated on 2026-05-15

Participants Needed

Research Sites

4 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are studying adult patients who are undergoing mechanical ventilation and preparing to be weaned off the ventilator. The study focuses on evaluating diaphragmatic effort and movement during a spontaneous breathing trial SBT, which involves no assistance from the ventilator. The goal is to explore new ways to assess diaphragm function using diaphragmatic longitudinal strain LSdi and strain rate LSRdi alongside existing measurements, to help detect diaphragmatic dysfunction earlier. Participants will be monitored during a spontaneous breathing trial lasting between 30 and 120 minutes, using continuous positive airway pressure CPAP with zero pressure support. Researchers will measure diaphragm function parameters, including diaphragmatic strain LSdi, LSRdi, thickening fraction TFdi, and airway occlusion pressures 94P0.1 and 94Pocc. These measurements will be taken at baseline before the trial, and then at 2 minutes early, 15 minutes intermediate, and 30 minutes late after the trial starts. During the study, patients will undergo regular assessments of diaphragm function using non-invasive imaging and pressure measurements. The research team aims to monitor changes in diaphragmatic longitudinal strain and strain rate throughout the SBT over a 7-day observation period. This detailed monitoring will help evaluate how the diaphragm performs during weaning from mechanical ventilation. Participants safety and clinical condition will be observed throughout the study period.

CONDITIONS

Brief Title

Diaphragmatic Speckle Tracking During Spontaneous Breathing Trial

Who Can Participate

Age: 18Years +

All Genders

Eligibility Criteria

You may qualify if you...

Adults 18 years or older undergoing mechanical ventilation for at least 24 hours
Patients eligible for a spontaneous breathing trial
Ability to trigger ventilator breaths with reasonable assistance
No severe impairment in gas exchange
No need for significant hemodynamic support
Informed consent provided by patient or authorized representative

You will not qualify if you...

Use of pressure support during the spontaneous breathing trial
Severe hemodynamic instability (more than 30% increase in vasopressors in last 6 hours or norepinephrine > 0.5 bcg/kg/min)
Severe or very severe COPD (stage III or IV by GOLD criteria)
Known or suspected severe or progressive neuromuscular disorder likely to cause prolonged ventilator dependence
Clinical judgment of attending physician

Research Team

Clément Brault, MD

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