Actively Recruiting
Diaphragmatic Speckle Tracking During Spontaneous Breathing Trial
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2026-05-15
60
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying adult patients who are undergoing mechanical ventilation and preparing to be weaned off the ventilator. The study focuses on evaluating diaphragmatic effort and movement during a spontaneous breathing trial (SBT), which involves no assistance from the ventilator. The goal is to explore new ways to assess diaphragm function using diaphragmatic longitudinal strain (LSdi) and strain rate (LSRdi) alongside existing measurements, to help detect diaphragmatic dysfunction earlier. Participants will be monitored during a spontaneous breathing trial lasting between 30 and 120 minutes, using continuous positive airway pressure (CPAP) with zero pressure support. Researchers will measure diaphragm function parameters, including diaphragmatic strain (LSdi, LSRdi), thickening fraction (TFdi), and airway occlusion pressures (94P0.1 and 94Pocc). These measurements will be taken at baseline before the trial, and then at 2 minutes (early), 15 minutes (intermediate), and 30 minutes (late) after the trial starts. During the study, patients will undergo regular assessments of diaphragm function using non-invasive imaging and pressure measurements. The research team aims to monitor changes in diaphragmatic longitudinal strain and strain rate throughout the SBT over a 7-day observation period. This detailed monitoring will help evaluate how the diaphragm performs during weaning from mechanical ventilation. Participants' safety and clinical condition will be observed throughout the study period.
CONDITIONS
Brief Title
Diaphragmatic Speckle Tracking During Spontaneous Breathing Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 18 years or older undergoing mechanical ventilation for at least 24 hours
- Patients eligible for a spontaneous breathing trial
- Ability to trigger ventilator breaths with reasonable assistance
- No severe impairment in gas exchange
- No need for significant hemodynamic support
- Informed consent provided by patient or authorized representative
You will not qualify if you...
- Use of pressure support during the spontaneous breathing trial
- Severe hemodynamic instability (more than 30% increase in vasopressors in last 6 hours or norepinephrine > 0.5 bcg/kg/min)
- Severe or very severe COPD (stage III or IV by GOLD criteria)
- Known or suspected severe or progressive neuromuscular disorder likely to cause prolonged ventilator dependence
- Clinical judgment of attending physician
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 7 days
Participants undergo diaphragmatic speckle tracking assessments during the spontaneous breathing trial to evaluate diaphragmatic function.
Daily assessments during the spontaneous breathing trial
Duration - Up to 7 days after the diagnostic evaluation
Participants are observed for changes in diaphragmatic function over time following the spontaneous breathing trial.
Follow-up visits as needed
Trial Site Locations
Total: 1 location
1
CHU Amiens
Amiens, France, 80480
Actively Recruiting
Research Team
C
Clément Brault, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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