Actively Recruiting
Diaphragmatic Training on GERD
Led by Changhua Christian Hospital · Updated on 2026-04-22
42
Participants Needed
1
Research Sites
134 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
he goal of this clinical trial is to evaluate the effects of diaphragm-oriented breathing training on patients with gastroesophageal reflux disease (GERD). This study will compare two non-invasive respiratory interventions-diaphragmatic breathing exercise (DBE) and volume-oriented incentive spirometry (VIS)-in terms of their impact on esophageal function and health-related quality of life.The main questions it aims to answer are:Does DBE or VIS improve GERD symptoms as measured by the GERD Questionnaire (GERDQ)?Do these interventions reduce esophageal acid exposure time and the number of reflux episodes?Do these interventions improve lower esophageal sphincter (LES) pressure and esophageal motility?Do these interventions improve GERD-related quality of life as measured by the GERD-HRQL questionnaire?Researchers will compare three groups: DBE, VIS, and a control group receiving standard care, to determine whether diaphragm-oriented breathing training provides additional benefits over usual management.Participants will:Be randomly assigned to one of three groups (DBE, VIS, or control)Perform the assigned intervention for 6 weeksUndergo baseline and post-intervention assessments, including symptom questionnaires and esophageal function testing Record symptoms and adherence in a daily diary
CONDITIONS
Official Title
Diaphragmatic Training on GERD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 20 and 80 years
- Confirmed diagnosis of gastroesophageal reflux disease (GERD) by at least one of the following:
- Endoscopic exam within past 3 months showing Los Angeles grade A reflux esophagitis with regular acid-suppressive medication use for over 2 months
- 24-hour esophageal pH monitoring with acid exposure time over 6%
- Endoscopic exam within past 3 months showing Los Angeles grade B or higher reflux esophagitis
- Willingness and ability to participate in the intervention, including adherence to training, follow-up visits, and assessments
You will not qualify if you...
- Pregnant or breastfeeding women
- History of anti-reflux or upper gastrointestinal surgery related to GERD
- Significant cardiopulmonary or chronic respiratory disease that may affect safety or ability to perform breathing training
- Inability to comply with study protocol due to cognitive impairment, physical limitations, or inability to attend visits
AI-Screening
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Trial Site Locations
Total: 1 location
1
Changhua Christian Hospital
Changhua, Changhua County, Taiwan, 50006
Actively Recruiting
Research Team
K
Kun-Chin Chou, MD
CONTACT
S
Shu-Ju Tu, NP, MSN/ PHD Candidate
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
3
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