Actively Recruiting
Diesel Exhaust Induces Glucocorticoid Resistance
Led by University of British Columbia · Updated on 2024-07-24
30
Participants Needed
1
Research Sites
369 weeks
Total Duration
On this page
Sponsors
U
University of British Columbia
Lead Sponsor
C
Canadian Institutes of Health Research (CIHR)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators are studying the effects of exposure to diesel exhaust on lung inflammation in the presence and absence of an inhaled corticosteroid. Although data is mixed, studies show that asthmatics have increased lung inflammation and worse symptoms during periods of higher air pollution despite taking their anti-inflammatory corticosteroid medication. One possible reason is that air pollution exposure may decrease the ability of corticosteroids to combat inflammation. To test this volunteers will inhale either a placebo or a corticosteroid, before sitting in an exposure booth for 2 hours breathing either filtered air or diluted diesel exhaust. Samples will be collected before and after exposure to analyze the effects of budesonide and diesel exhaust exposure.
CONDITIONS
Official Title
Diesel Exhaust Induces Glucocorticoid Resistance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 19 to 49 years
- Physician-diagnosed asthma confirmed by study physician examination
- Confirmed asthma diagnosis by spirometry, methacholine challenge with PC20 less than 16 mg/mL, and questionnaires during screening visit
You will not qualify if you...
- Smoking of any kind (more than 0.5 pack-years ever or current smoking) or use of vape/vaporizing devices
- Regular use of anti-histamines, NSAIDs, corticosteroids, or other controller medications
- Pregnancy or breastfeeding
- Methacholine PC20 greater than 16 mg/mL
- Relevant cardiac condition or arrhythmia
- Body mass index over 35
- Participation in another study that could interfere
- Use of inhaled or oral corticosteroids in the past 6 months
- Substantial comorbidities or other concerns by study physician
- Scheduled surgery before study completion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of British Columbia
Vancouver, British Columbia, Canada, V5Z1M9
Actively Recruiting
Research Team
P
Parteek (PJ) Johal, BCS
CONTACT
A
Agnes CY Yuen, BSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here