Actively Recruiting
Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
Led by National Institutes of Health Clinical Center (CC) · Updated on 2026-04-16
80
Participants Needed
1
Research Sites
292 weeks
Total Duration
On this page
Sponsors
N
National Institutes of Health Clinical Center (CC)
Lead Sponsor
N
National Human Genome Research Institute (NHGRI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Background: Sickle Cell Disease (SCD) causes blood cells form a crescent shape. It is caused by a genetic mutation in the hemoglobin gene. People with SCD are at increased risk for illnesses like stroke, chronic pain, and heart problems, as well as decreased overall health and well-being. Researchers want to learn more about how nutrition and diet can help relieve or reduce the symptoms of SCD. Objective: To understand how diet, dietary patterns and behaviors, nutrition, and other related factors in adults with SCD affect their overall health. Eligibility: Adults aged 18 and older with SCD. Design: Participants will be screened with a review of their medical records. They will take a pregnancy test if needed. Participants will have a physical exam and medical history. Their height, weight, and waist and hip circumference will be measured. They can complete this exam (1) via telehealth along with a visit to an outpatient laboratory center or (2) by going to the NIH Clinical Center. Participants will complete 2 interviews about their diet. They will talk about the foods they ate in the past 24 hours. They will also complete 1 interview about diet-related behaviors such as food shopping and cooking. They can complete the interviews in person, by phone, or by telehealth visit. Participants will complete surveys about their demographics (such as age and gender), SCD pain, mood, stress, diet, and nutrition. It may take about 1 hour to complete all of the surveys. Participants will give blood and urine samples. They will need to fast for at least 8 hours overnight before giving blood samples. Participation will last for about 2 weeks.
CONDITIONS
Official Title
Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing to complete all study procedures for the duration of the study
- 18 years of age or older at the time of screening
- Have a documented clinical diagnosis of Sickle Cell Disease or a hemoglobinopathy genotype of HbSS, HgSC, HbSB 0, or HBSB+ confirmed by medical records
You will not qualify if you...
- Less than 18 years of age
- Unable to speak, read, write, or understand English
- Have a condition or illness that prevents giving informed consent, such as cognitive impairment
- Have Sickle Cell Trait genotype
- Currently receiving inpatient treatment in any hospital for Sickle Cell Disease at screening
- Pregnant at the time of screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
S
Stephanie L Wildridge, R.N.
CONTACT
N
Nicole M Farmer, M.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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