Actively Recruiting
Dietary Intervention on Atopy to Reduce Severity of Atopic Dermatitis Using a Healthy Diet Pattern
Led by National University of Singapore · Updated on 2026-04-01
110
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are exploring how diet affects atopic dermatitis (AD), a chronic inflammatory skin condition that often starts early and can impact quality of life, sleep, and mental well-being. This study aims to understand whether a healthy dietary pattern, adapted to local guidelines, can reduce AD severity in young adults. The trial focuses on whole-diet changes rather than single nutrients and addresses a gap in research among Asian adult populations. Participants are randomly assigned to one of two groups for a 2-month period. The intervention group receives daily bento-style meals for lunch and dinner, prepared by a licensed catering service, featuring whole grains, lean proteins, fruits, vegetables, and healthy fats. The control group continues with their usual diet without receiving meals or nutritional advice. After the intervention, a follow-up occurs one month later to assess lasting effects. Throughout the study, participants undergo assessments at the start, after 2 months, and at 1 month post-intervention. Researchers measure AD severity using SCORAD scores, skin barrier function, quality of life specific to dermatology, medication use, body measurements, blood pressure, blood lipid profiles, inflammatory markers, and gut microbiota composition. The study tracks adherence and changes to understand the diet's impact on AD and overall health.
CONDITIONS
Brief Title
Dietary Intervention on Atopy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Current mild-to-moderate atopic dermatitis or eczema at flexural areas
- Aged 21 to 65 years inclusive at screening
- Able to read and understand English and provide informed consent
- Residing in Singapore without plans to travel outside during the study
- Willing and able to follow study procedures and available for study duration
- Non-smoker (no tobacco or e-cigarette use)
- Non-drinker (no regular or frequent alcohol consumption)
- Generally healthy without major medical conditions such as diabetes, hypertension, cancer, immune or psychiatric disorders
- No known food allergies to study foods
- No fear of needles
- Willing to follow instructions on use of moisturisers, cosmetics, and topical creams throughout the study
You will not qualify if you...
- Participating in other research studies concurrently
- Pregnant or breastfeeding
- History of psychiatric disorders within the past 3 years
- Known severe nutritional deficiency
- Vegetarian or vegan diet
- Significant dietary changes made in the past 12 months
- Pre-existing dietary restrictions that interfere with adherence to the study diet
- Regular use of strong medications, therapies, or alternative medicines
- Use of nutritional supplements in the past 12 months
- Regular use of oral contraceptives or steroid hormones
- Antibiotic use in the past 2 months
- Hospitalisation or surgery within 6 months before study enrolment
- Significant weight change (+/- 5%) in the past month
- History of bleeding disorders
- Blood donation of more than 500 mL within 4 weeks before study start
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 2 months
Participants in the intervention arm follow a healthy dietary pattern with provided meals for lunch and dinner daily for 2 months. Control participants continue their usual dietary habits without nutritional advice or provided meals.
Daily meal provision for intervention group; control group follows usual diet
Duration - 1 month
Participants are monitored for 1 month after the intervention to assess longer-term effects on atopic dermatitis severity and related health measures.
1 follow-up visit
Trial Site Locations
Total: 1 location
1
National University of Singapore
Singapore, Singapore, Singapore, 118177
Actively Recruiting
Research Team
M
Mei Hui Liu, PhD
J
Jun Jie Lim, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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