Dietary Intervention to Mitigate Adverse Consequences of Night Work

What this Trial Is About

This research aims to evaluate whether a specific dietary intervention can prevent or reduce the negative health consequences of night shift work in healthy adults aged 18 to 45 years. The study focuses on the metabolic effects caused by circadian misalignment due to shift work, which may increase diabetes risk. Researchers hope to develop tailored dietary strategies to support metabolic health for shift workers. Participants will undergo two inpatient stays during which they will receive identical meals under two different dietary conditions. The study uses a randomized, single-blind design where participants receive either the control diet first followed by the dietary intervention, or vice versa. Details of the dietary intervention are kept confidential during the recruitment phase and will be disclosed after enrollment closes. Throughout the study, participants will provide frequent blood samples and various biological specimens including urine, saliva, stool, and rectal swabs. Researchers will measure changes in glucose tolerance and gut and oral microbiome profiles from baseline to test days. Additional assessments include insulin sensitivity and markers related to gut microbiota, intestinal barrier integrity, and inflammation. These evaluations help determine the intervention's impact on metabolic health during night shift conditions.

Dietary Intervention to Mitigate Adverse Consequences of Night Work