Dietary Potassium Liberalization With Fruit and Vegetables Versus Potassium Restriction in People With Chronic Kidney Disease Trial

What this Trial Is About

Researchers are investigating how the potassium content in fruits and vegetables affects blood potassium levels in people with Chronic Kidney Disease (CKD). The study aims to provide high-quality evidence to guide dietary potassium recommendations, which currently rely on low-quality data. This research also explores whether a diet higher in potassium from fruits and vegetables might improve quality of life for people with CKD. In this 16-week randomized crossover trial, participants will receive deliveries of fruits and vegetables with either higher or lower potassium content in a random order. Each treatment period lasts 6 weeks, separated by a 2-week washout period. During each period, participants will have a dietary counseling session with a registered dietitian to help incorporate the assigned fruits and vegetables into their regular diet. The potassium-rich foods will aim for about 2000 mg of potassium daily from the delivered produce, while the lower potassium foods will provide less than 500 mg daily. Participants will be monitored throughout the trial with blood and urine tests to measure potassium and other markers, blood pressure checks, and assessments of physical function using a chair stand test. Quality of life related to physical function will also be evaluated. The main outcome is the change in blood potassium levels between the two treatment periods. This study will last about 16 weeks and may influence future dietary advice for people with CKD regarding potassium intake.

Dietary Potassium Liberalization in Pre-Dialysis Patients