Study of Plant-Derived Supplements to Increase Fat Burning in Overweight and Obese Adult Women

What this Trial Is About

Researchers are studying the effects of daily consumption of encapsulated N-trans-caffeoyl tyramine NCT and N-trans-feruloyl tyramine NFT over four weeks on fat burning in adult women with overweight or obesity. The trial aims to compare fat oxidation at rest and over a 24-hour period between women receiving the active supplement and those given a control product. This pilot study is sponsored by Brightseed and uses a randomized, double-blind design to ensure reliable results. Participants will receive either a dietary supplement containing plant-derived phenolics or a placebo made of microcrystalline cellulose. The supplement dose is 120 mg per day, taken daily for four weeks. The study design involves two groups with treatments given in a blinded manner, meaning neither participants nor researchers know who receives the active supplement or placebo until the study ends. During the trial, women will undergo measurements on day 1 and day 28, including fat oxidation assessed by a special stable isotope tracer test at multiple time points across 24 hours, and indirect calorimetry to measure energy use. Other assessments include cardiometabolic health parameters and body weight changes. Participants will keep diet records using a personal device app and follow study procedures closely. The entire study participation lasts about four weeks, with safety and adherence monitored throughout.

Dietary Supplementation on Fat Oxidation