Effects of Creatine and Dietary Supplements on Health and Wellbeing in Healthy Women Aged 35 to 65

What this Trial Is About

This research aims to evaluate the effects of combining dietary supplements on various health and wellbeing aspects in healthy middle-aged women aged 35 to 65. It focuses on common issues such as joint pain, fatigue, sleep quality, body composition changes, strength, and inflammation. The study uses a randomized, triple-blind design to compare creatine monohydrate versus maltodextrin placebo over eight weeks. Participants will be randomly assigned to take either creatine about 6 grams per day or a placebo maltodextrin supplement about 10 grams per day daily for eight weeks. Before starting supplementation, participants complete familiarization visits involving cognitive tests, food diaries, and questionnaires assessing physical activity, quality of life, sleep, menstrual or menopause symptoms. Physical measures including body composition, blood pressure, handgrip strength, and blood samples for inflammation and joint health markers are collected. After eight weeks of supplementation, assessments are repeated in a final visit. Throughout the study, participants track supplement intake and maintain diet and activity levels. Researchers assess cognitive function as the primary outcome, along with body composition, muscle strength, blood pressure, fatigue, sleep quality, quality of life, gastrointestinal comfort, joint pain, and menopause symptoms. The study includes detailed questionnaires, physical measures, and blood tests before and after supplementation to monitor changes. The total participation duration spans about eight weeks following initial assessments.

Dietary Supplements and Middle Aged Women (Creatine)