Actively Recruiting
Dietary and Topical Magnesium Replacement or Supplementation in Patients With Lymphoma
Led by Mayo Clinic · Updated on 2026-03-16
60
Participants Needed
1
Research Sites
258 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This early phase I trial investigates the effect of dietary and topical magnesium replacement on magnesium blood levels in patients with lymphoma. Magnesium is an element in the body that is important to cell health. The body cannot make magnesium and it typically comes from the food we eat. In patients who are ill, magnesium is often replaced intravenously (IV) through a vein or by mouth. This study may help researchers find out if being on a magnesium rich diet and using a magnesium lotion on the skin helps to keep magnesium blood levels in an ideal range. This study also investigates side effects and quality of life when receiving different forms of magnesium.
CONDITIONS
Official Title
Dietary and Topical Magnesium Replacement or Supplementation in Patients With Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age �3e= 18 years
- Currently have or have had any type of lymphoma
- If previously treated, off myelosuppressive chemotherapy with no planned chemotherapy for �3e= 2 months or on rituximab maintenance or chronic oral therapies such as BTK inhibitors, venetoclax, tazemetostat, or corticosteroids
- Able to eat a full range of solid foods and liquids and tolerate seeds/nuts
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0, 1, or 2
- Provide written informed consent
- Able to recall dietary intake for the prior 24 hours and complete a one-day food record with dietitian assistance at each visit
- Willing to attend baseline, 4 weeks, and 8 weeks visits in person or by video/phone
- Willing to have blood magnesium checked every 2 weeks up to 4 times at any Mayo Clinic site
- Ability to complete questionnaires independently or with help
- Magnesium level of 1.5 - 1.9 mg/dL obtained within 5 days prior to registration
You will not qualify if you...
- Cannot eat normal table food by mouth including patients with feeding tubes or swallowing disorders
- Taken dedicated magnesium supplements or IV magnesium within 28 days prior to pre-registration
- Have active infections or severe diseases that interfere with safety or assessment
- Significant gut malabsorptive conditions or chronic kidney disease stage 3b or worse (eGFR < 45)
- Uncontrolled illnesses such as infections, heart failure, unstable angina, arrhythmia, or psychiatric/social issues limiting compliance
- Receiving other investigational agents for lymphoma or other diseases
- Active other cancers requiring treatment interfering with study assessments
- Major surgery other than diagnostic surgery within 4 weeks prior to pre-registration
- Allergy to nuts
- Active skin lymphoma or rashes preventing lotion use
- Taken antibiotics within 7 days prior to pre-registration
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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