Actively Recruiting
Dietary Treatment Strategies and Metabolic Control in Glycogen Storage Disease Type I
Led by Insel Gruppe AG, University Hospital Bern · Updated on 2026-05-12
20
Participants Needed
2
Research Sites
96 weeks
Total Duration
On this page
Sponsors
I
Insel Gruppe AG, University Hospital Bern
Lead Sponsor
U
University of Zurich
Collaborating Sponsor
AI-Summary
What this Trial Is About
The present project will specifically assess metabolic effects of dietary interventions with controlled intake of fructose and fructose/galactose in GSDI, with the aim to provide evidence whether relaxed dietary restrictions of fructose and galactose may be justified in treatment recommendations at least for adults, which would considerably enlarge food choice in everyday life of the patients with an expected positive impact on the quality of life of patients with this rare disorder.
CONDITIONS
Official Title
Dietary Treatment Strategies and Metabolic Control in Glycogen Storage Disease Type I
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Genetically and/or enzymatically confirmed diagnosis of GSDI (GSDIa or GSDIb)
- Male or female aged 18 years or older
- Restriction of fructose intake in usual dietary treatment
- Written informed consent
You will not qualify if you...
- Non-compliance with routine dietary treatment
- Pregnancy or lactation
- Liver transplant
- Recurrent hospitalisations due to metabolic decompensation within the last 12 months
- Severe chronic kidney disease with glomerular filtration rate (GFR) < 30 ml/min
- For GSDIb: Severe, uncontrolled symptomatic inflammatory bowel disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital
Bern, Switzerland, 3010
Actively Recruiting
2
Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich
Zurich, Switzerland, 8091
Not Yet Recruiting
Research Team
M
Michel Hochuli, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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