Actively Recruiting
Effects of Dietary Wild Blueberries on Gut Health and Inflammation and Joint Pain
Led by University of Nevada, Las Vegas · Updated on 2025-11-05
50
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
Sponsors
U
University of Nevada, Las Vegas
Lead Sponsor
O
Oklahoma Medical Research Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are studying how dietary wild blueberries affect gut microbiome, inflammation markers in the blood, and joint function in adults with arthritis. The study aims to better understand the potential relationship between blueberry consumption and joint health. This is a randomized, double-blind trial sponsored by the University of Nevada, Las Vegas, focusing on adults aged 40 to 75 years with multi-joint or knee arthritis. Participants will be randomly assigned to consume either 25 grams of freeze-dried wild blueberry powder or a placebo powder without polyphenols but matched for calories daily for 12 weeks. There is a 2-week washout phase between treatment periods. The study involves two groups: one taking the blueberry supplement and the other taking the matched placebo. During the study, participants will have their joint function assessed through blood tests measuring serum biomarkers after 12 weeks. Researchers will also analyze changes in the gut microbiome. The study includes monitoring for signs of inflammation and joint pain. Participants will attend scheduled visits for assessments throughout the trial, which lasts approximately three months.
CONDITIONS
Brief Title
Dietary Wild Blueberries and Joint Health
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults with documented multi-joint or knee arthritis
You will not qualify if you...
- Inability to give informed consent
- Pregnancy or lactation
- Planned knee replacement surgery
- Allergy or contraindication to berries
- Recent trauma of the knee responsible for the symptomatic knee
- Intra-articular injection in the target knee or hip in the last 3 months
- Oral corticosteroid therapy 25 mg/day (prednisone equivalent) at baseline
- Use of berry extracts in the last 3 months
- Special diets
- Cancer treatment
- Bone diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 12 weeks per intervention period
Participants receive either 25g of freeze-dried wild blueberry powder daily or a placebo powder without polyphenols, each for 12 weeks, in a randomized crossover design.
Visits scheduled according to study protocol during each 12-week treatment period
Trial Site Locations
Total: 1 location
1
OMRF
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
Research Team
A
Arpita Basu
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
OTHER
Number of Arms
2
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