Actively Recruiting
Differences in N-CAD Concentration and Brain Function Between Children With ASD and TD
Led by Chen Li · Updated on 2026-02-10
98
Participants Needed
1
Research Sites
14 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The incidence of autism spectrum disorders is increasing, about 1 / 36. Neural cadherin (NCAD) is closely related to synaptic structure and function. The cdh2 gene encoding NCAD has been shown to be associated with a variety of neurodevelopmental diseases and is one of the six risk genes for ASD. Functional near-infrared spectroscopy (fNIRS) is a neuroimaging technology that uses the principle of near-infrared spectroscopy to detect the functional activation of human cortex. The application of fNIRS to explore the neural mechanism of children with ASD has developed rapidly. It has the advantages of non-invasive, portable, relatively low cost and unlimited physical activity. And for ASD children, their command compliance and self-control are relatively low, so fNIRS is more widely used in ASD children. According to dsm-5 standard, we recruited ASD children and TD children, collected their peripheral blood, and detected the plasma n-cad concentration. At the same time, the resting state of fNIRS of the two groups of children was collected, and the ultra scan monitoring was carried out simultaneously during Gesell assessment. The purpose of this study was to explore the difference of peripheral blood NCAD concentration between preschool ASD children and TD children and the difference of brain function in resting state and social interaction state. And the relationship between the characteristics of brain function and the level of cognitive development in children with ASD.
CONDITIONS
Official Title
Differences in N-CAD Concentration and Brain Function Between Children With ASD and TD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age at enrollment 3 years or older and less than 5 years
- Diagnosis of autism spectrum disorder by two developmental behavioral pediatricians or child psychiatrists with appropriate qualifications
- Diagnosis and history in line with ASD and ICD-11 criteria
You will not qualify if you...
- Diagnosis or symptoms of genetic diseases or syndromes related to ASD, such as Rett syndrome
- Presence of medical or nervous system diseases affecting growth, development, or cognition, such as central nervous system infection, epilepsy, or congenital heart disease
- Sensory impairments including vision or hearing loss
- Low birth weight (under 2000 g) or preterm birth (gestational age less than 37 weeks)
- Adopted children
- Parents refuse to sign informed consent
- Considered inappropriate to participate by other researchers
AI-Screening
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Trial Site Locations
Total: 1 location
1
Growth, Development and Mental health of Children and Adolescence Center
Chongqing, Chongqing Municipality, China, 400014
Actively Recruiting
Research Team
L
Li Chen, doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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