Study of N-CAD Levels and Brain Activity Differences in Children Aged 3 to 5 With Autism Spectrum Disorder Compared to Typically Developing Children

What this Trial Is About

Researchers are examining differences in neural cadherin NCAD levels and brain function between preschool children with autism spectrum disorder ASD and typically developing TD children. The study focuses on NCAD, a protein related to synaptic function, and uses functional near-infrared spectroscopy fNIRS to explore brain activity in resting and social interaction states. The goal is to understand how brain function characteristics relate to cognitive development in children with ASD. Children aged 3 to under 5 years with ASD or typical development are enrolled. Blood samples are collected to measure plasma NCAD concentration, and brain activity is recorded using fNIRS while children are at rest and during the Gesell developmental assessment. The TD group is matched to the ASD group by age and gender, ensuring normal developmental levels. Participants undergo physical measurements, blood and nutrient tests, neuropsychological assessments, and fNIRS imaging. Caregivers complete demographic questionnaires, and clinical data are verified from medical records. The study measures NCAD levels and brain function at baseline, analyzing data for correlations with developmental quotients. Ethical approval and informed consent are secured, with privacy protections in place. The study aims to include 49 children in each group and monitors data quality and safety throughout.

Differences in N-CAD Concentration and Brain Function Between Children With ASD and TD