Actively Recruiting
Differences in Prosocial Behaviors and Related Brain Networks in Children With Autism and Typical Development
Led by Children's Hospital of Fudan University · Updated on 2025-05-29
300
Participants Needed
1
Research Sites
220 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital of Fudan University
Lead Sponsor
S
ShanghaiTech University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to compare the brain functional network between children with autism and typical development, using magnetic resonance imaging (MRI), electroencephalogram/event-related potentials(EEG/ERPs) and functional Near Infrared Spectrum(fNIRs). The main questions it aims to answer are as follows: 1. What are the differences of the functional brain network between autism and TD children? 2. What are the differences of the brain activity in response to special social stimulus between autism and TD children? Participants will receive developmental/intelligence assessments (Griffiths Mental Developmental Scales/Wechsler Preschool and Primary Scale of Intelligence-IV/Wechsler Intelligence Scale for Children-IV for children of different ages), social assessments(Autism Diagnostic Observation Schedule-2nd Edition/Social Communication Questionnaire), EEG/ERPs and fNIRs in resting and task states, and head MRI in natural sleeping state(without sedative).
CONDITIONS
Official Title
Differences in Prosocial Behaviors and Related Brain Networks in Children With Autism and Typical Development
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children diagnosed with autism spectrum disorder based on clinical judgement and confirmed with ADOS-2
- Ages between 2 and 17 years
- Parents or caregivers understand the study and agree to participate
- Healthy children aged 2 to 17 years
- Children without family history of autism or other neurodevelopmental or mental diseases
- Parents or caregivers understand the study and agree to participate
You will not qualify if you...
- Diagnosis of Rett Syndrome, Fragile X Syndrome, Angelman Syndrome, Prader-Willi Syndrome, tuberous sclerosis, or other syndromes caused by known genetic or metabolic diseases
- Children with brain injuries, specific chronic or congenital diseases
- Gestational age less than 37 weeks or birth weight below 2500 grams
- Children unable to undergo head MRI examination
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Children's Hospital of Fudan University
Shanghai, China
Actively Recruiting
Research Team
B
Bingrui Zhou
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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