What is amoxicillin studying for erythema migrans?

This study is evaluating different durations of amoxicillin treatment in patients with erythema migrans, an early sign of Lyme borreliosis. The goal is to find out which treatment plan best manages symptoms and prevents further complications. The University Medical Centre Ljubljana is leading this research.

Who may be eligible for this erythema migrans clinical trial?

Adults aged 18 and older with erythema migrans may be eligible. The study accepts all genders but excludes those who are pregnant, have serious reactions to beta-lactam antibiotics, or have recently taken antibiotics for Lyme disease. Please review eligibility criteria for more details.

Is there any cost to participate in this erythema migrans clinical trial?

Study-related care, including the study drug and all trial visits, is provided at no cost. However, personal travel expenses may vary and are not guaranteed to be covered. Participants should plan accordingly.

Actively Recruiting

Phase 3

Age: 18Years +

All Genders

Healthy Volunteers

ID03966014

Comparing Different Lengths of Amoxicillin Treatment for Erythema Migrans A Phase 3 Randomized Clinical Trial

Led by University Medical Centre Ljubljana · Updated on 2026-03-25

200

Participants Needed

Research Sites

N/A

Total Duration

AI-Summary

What this Trial Is About

Researchers are comparing different treatment plans using amoxicillin in patients diagnosed with erythema migrans. The study aims to assess how effective these treatments are in managing symptoms and signs related to Lyme borreliosis. It is a Phase 3 clinical trial sponsored by the University Medical Centre Ljubljana to better understand treatment duration and dosage effects. Participants will be randomly assigned to one of three groups one receiving amoxicillin 500 mg three times a day for 10 days, another receiving the same dose for 14 days, and a control group without Lyme borreliosis receiving no intervention. This design allows comparison of two active treatment durations against a control group. During the study, researchers will monitor patients for one year to observe the occurrence of objective signs or subjective symptoms of Lyme borreliosis after treatment. They will also track nonspecific symptoms. The trial involves regular follow-ups to evaluate these outcomes and assess overall patient health related to the condition and treatments.

CONDITIONS

Brief Title

Different Amoxicillin Treatment Regimens in Erythema Migrans Patients

Who Can Participate

Age: 18Years +

All Genders

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Have erythema migrans
Be 18 years of age or older

You will not qualify if you...

Are pregnant
Have extracutaneous manifestations of Lyme borreliosis
Have an immunocompromising condition
Have had a serious adverse reaction to beta-lactam antibiotics
Have taken antibiotics active against Lyme disease within the last 10 days

Research Team

Daša Stupica, MD PhD

Maša Velušček, MD

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