Actively Recruiting

Phase Not Applicable
Age: 18Years - 80Years
All Genders
ID06936904

Impact of Different Injection Rate on Local Anaesthetic Spread of Ultrasound-guided Erector Spinae Plane Block

Led by Nanjing First Hospital, Nanjing Medical University · Updated on 2025-05-22

74

Participants Needed

1

Research Sites

12 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to examine how different injection speeds affect the spread of local anesthetic during ultrasound-guided erector spinae plane block (ESPB) in patients who are undergoing CT-guided lung nodule localization. The main question is whether injecting 30 ml of anesthetic over 30 seconds results in a different distribution compared to injecting the same volume over 180 seconds. Seventy-four patients scheduled for this procedure were randomly assigned to two groups to compare these injection speeds. Patients in both groups receive an ultrasound-guided ESPB before the CT-guided lung nodule localization. Using a high-frequency linear probe, the anesthetic solution, which includes ropivacaine and iodinated contrast, is injected between the transverse process and erector spinae muscles. The control group receives 30 ml of anesthetic over 180 seconds, while the experimental group receives the same volume over 30 seconds. After 30 minutes, CT scans with 3D reconstructions are performed to evaluate the spread of anesthetic. Participants undergo assessments including CT imaging to measure anesthetic spread to various spaces such as the paravertebral, intercostal, epidural spaces, and neural foramina. Sensory loss and pain scores are recorded, along with heart rate and blood pressure monitoring before and after the block at several time points. The study lasts through the procedure, with outcomes assessed 30 minutes to one hour after the block to understand the effects of injection speed on anesthetic distribution and patient response.

CONDITIONS

Brief Title

Different Injection Speed on Local Anaesthetic Spread of ESPB

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients scheduled for CT-guided lung nodule localization under local anesthesia
  • Aged 18 to 80 years
  • Body mass index (BMI) between 18 and 30 kg/m²
  • ASA classification I to III
Not Eligible

You will not qualify if you...

  • Allergy to the study drug or to local anesthetics
  • History of opioid abuse
  • Previous infection at the erector spinae plane block or paravertebral block puncture site
  • Peripheral neuropathy
  • Dysfunction of blood coagulation

AI-Screening

AI-Powered Screening

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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Approximately 30 minutes

Participants undergo ultrasound-guided erector spinae plane block with local anesthetic injected at different speeds before CT-guided lung nodule localization.

1 visit (in-person)

Follow-up

Duration - Up to 1 hour after procedure

Participants are monitored for the spread of local anesthetic and hemodynamic responses after the block and lung nodule localization procedure.

1 follow-up visit (in-person)

Trial Site Locations

Total: 1 location

1

Nanjing First Hospital

Nanjing, Jiangsu, China

Actively Recruiting

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Research Team

T

Tao Shan

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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