Actively Recruiting
Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION）
Led by Zhejiang Cancer Hospital · Updated on 2024-12-02
214
Participants Needed
1
Research Sites
88 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a randomized controlled study to explore whether perioperative blood pressure management with different strategies can reduce the incidence of delirium and postoperative cognitive impairment and serious perfusion related complications (persistent hypotension, new heart arrhythmia, cardiac insufficiency, new stroke, sudden death, etc.) within 30 days after stroke in cancer patients at high risk for stroke. Patients were randomly divided into: 1) strict blood pressure management group: norepinephrine or phenylephrine maintenance intraoperative MAP≥85 mmHg, and 2) conventional blood pressure management group: intraoperative routine blood pressure management (MAP≥65mmHg). The study included 424 subjects and was randomized to provide 90% efficacy. Secondary markers were unscrupulous cerebrovascular events (persistent hypotension, arrhythmia, cardiac insufficiency, new stroke, sudden death) within 30 days after surgery.
CONDITIONS
Official Title
Different Intraoperative Blood Pressure Management on Postoperative Cognitive Function in Tumor Patients（PRECISION）
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with high-risk stroke (combined with 3 risk factors or more according to the stroke risk screening table)
- Patients who plan to undergo surgery for abdominal tumors (gynecological, urinary, hepatobiliary, and gastrointestinal tumors) under general anesthesia with expected surgery duration over 2 hours
- ASA classification of Class II or III
- Patients who had invasive arterial blood pressure monitoring before surgery and signed informed consent
You will not qualify if you...
- Patients who do not want to participate in the study
- Severe heart disease such as severe valvular disease, sick sinus syndrome, or high atrioventricular block without pacemaker
- Grade III or above liver function impairment (Child-Pugh class C)
- Need for kidney replacement therapy
- New stroke within 3 months
- Emergency surgery
- History of mental illness, epilepsy, Parkinson's disease, or myasthenia gravis
- Speech, vision, or hearing impairment preventing completion of cognitive function assessment
- Situations where strict blood pressure management is not appropriate, such as controlled hypotension during surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zhejiang Cancer Hospital
Hangzhou, Zhejiang, China, 310022
Actively Recruiting
Research Team
Y
yejing Zhu, PHD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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