Actively Recruiting
Differential Assessment of Hypertonia
Led by Chang Gung University · Updated on 2024-10-15
45
Participants Needed
1
Research Sites
94 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements. Spasticity is characterized by a velocity-dependent increase in stretch reflexes, accompanied by exaggerated tendon responses, while rigidity is marked by consistent resistance throughout the range of motion, traditionally considered independent of stretch velocity. However, recent studies suggest that rigidity may also be influenced by stretch velocity. This study aims to investigate muscle tone by examining spasticity, rigidity, and normal muscle function through neural and biomechanical changes. Standard clinical tools, such as the Modified Ashworth Scale and Unified Parkinson's Disease Rating Scale, along with additional assessments like the Myoton and Post-Activation Depression (PAD), will be employed.
CONDITIONS
Official Title
Differential Assessment of Hypertonia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with chronic spinal cord injury with duration greater than one year
- Clinical diagnosis of Parkinson's disease
You will not qualify if you...
- Musculoskeletal injuries on legs
- Osteoporosis
- History of central or peripheral neuromuscular diseases
- Presence of a pacemaker
- Current use of antispastic or antidepressant medications
- Current venous thromboembolism
- Impairment of the soleus H-reflex arc
- Any peripheral or central nervous system injury or disease (for Parkinson's disease subjects)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Chang Gung University
Taoyuan, Taiwan, 333
Actively Recruiting
Research Team
Y
Ya-Ju Chang, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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