Actively Recruiting
Differential Assessment of Hypertonia Related to Central Nervous System Impairment
Led by Chang Gung University ยท Updated on 2024-10-15
45
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating muscle tone differences in people with central nervous system injuries such as spinal cord injury and Parkinson's disease. These injuries can cause spasticity and rigidity, which are different patterns of increased resistance during passive joint movements. The study aims to explore neural and biomechanical changes affecting muscle tone using clinical tools like the Modified Ashworth Scale, Unified Parkinson's Disease Rating Scale, and additional devices such as the Myoton and Post-Activation Depression (PAD) measurements. Participants will undergo procedures involving a continuous passive motion device (CPM) applied to the ankle at two different speeds: fast (1 Hz, 60 rpm) and slow (0.25 Hz, 15 rpm), each for 10 repetitions. The study includes healthy volunteers, Parkinson's disease patients, and spinal cord injury patients. These procedures help assess relationships between foot pressure changes, muscle tone, and PAD. During the study, researchers will measure several outcomes before and immediately after CPM treatment, including H-reflex amplitude, M-wave amplitude and latency, muscle tone frequency, elasticity, stiffness, mechanical stress and relaxation, plantar foot pressure, and the H/M ratio. These assessments will provide detailed information on muscle function and neural responses. The study is non-randomized and open-label, with participants monitored continuously during interventions. The study is expected to continue until August 2026.
CONDITIONS
Brief Title
Differential Assessment of Hypertonia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 20 years or older
- Clinical diagnosis of Parkinson's disease (for PD subjects)
- Chronic spinal cord injury with injury duration greater than one year (for SCI subjects)
You will not qualify if you...
- Musculoskeletal injuries on legs
- Osteoporosis
- History of central or peripheral neuromuscular diseases (SCI subjects)
- Presence of a pacemaker (SCI subjects)
- Current use of antispastic or antidepressant medications (SCI subjects)
- Current venous thromboembolism or osteoporosis (SCI subjects)
- Impairment of the soleus H-reflex arc (SCI subjects)
- Any peripheral or central nervous system injury or disease other than specified (PD subjects)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Single session
Participants undergo continuous passive motion of the ankle at two different speeds to assess muscle tone and neural responses.
1 visit (in-person) with continuous measurement during procedures
Trial Site Locations
Total: 1 location
1
Chang Gung University
Taoyuan, Taiwan, 333
Actively Recruiting
Research Team
Y
Ya-Ju Chang, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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