Study of Muscle Tone Differences in Spasticity and Rigidity Related to Central Nervous System Injuries including Parkinsons Disease and Spinal Cord Injury

What this Trial Is About

Researchers are investigating muscle tone differences in people with central nervous system injuries such as spinal cord injury and Parkinsons disease. These injuries can cause spasticity and rigidity, which are different patterns of increased resistance during passive joint movements. The study aims to explore neural and biomechanical changes affecting muscle tone using clinical tools like the Modified Ashworth Scale, Unified Parkinsons Disease Rating Scale, and additional devices such as the Myoton and Post-Activation Depression PAD measurements. Participants will undergo procedures involving a continuous passive motion device CPM applied to the ankle at two different speeds fast 1 Hz, 60 rpm and slow 0.25 Hz, 15 rpm, each for 10 repetitions. The study includes healthy volunteers, Parkinsons disease patients, and spinal cord injury patients. These procedures help assess relationships between foot pressure changes, muscle tone, and PAD. During the study, researchers will measure several outcomes before and immediately after CPM treatment, including H-reflex amplitude, M-wave amplitude and latency, muscle tone frequency, elasticity, stiffness, mechanical stress and relaxation, plantar foot pressure, and the HM ratio. These assessments will provide detailed information on muscle function and neural responses. The study is non-randomized and open-label, with participants monitored continuously during interventions. The study is expected to continue until August 2026.

Differential Assessment of Hypertonia