Actively Recruiting
Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries.
Led by Beijing Tsinghua Chang Gung Hospital · Updated on 2025-05-15
800
Participants Needed
1
Research Sites
169 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to investigate the impact of hepatic ischemia-reperfusion injury (HIRI) on the incidence of myocardial injury after non-cardiac surgery (MINS) and explore the potential underlying mechanisms. A bidirectional cohort study will be conducted, enrolling patients scheduled for major hepato-biliary surgery. Clinical data, perioperative parameters, and postoperative follow-up data will be systematically collected. The incidence of MINS between patients undergoing Pringle occlusion and portal vein occlusion will be compared, and a multivariate analysis will be performed to identify independent risk factors for MINS, providing a basis for early recognition and prevention of MINS.
CONDITIONS
Official Title
Differential Impact of Pringle and Portal Vein Occlusion on Myocardial Injury After Non-Cardiac Surgeries.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 65 years or older, or 45 years or older with cardiovascular risk factors (especially known cardiovascular disease)
- Undergoing elective major hepatopancreatobiliary surgery under general anesthesia
- ASA physical status II-III
- Provide written informed consent to participate in the study (for prospective cohort)
You will not qualify if you...
- Emergency surgery
- Preoperative diagnosis of myocardial infarction or unstable angina
- Severe hepatic insufficiency (Child-Pugh class C)
- Concomitant severe organ dysfunction such as renal failure or respiratory failure
- Active infectious disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine，Tsinghua University
Beijing, Beijing Municipality, China, 102218
Actively Recruiting
Research Team
Z
Zhifeng Gao, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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