Actively Recruiting
Differential Thrombogenesis by EPA and DHA Mediated by HDL
Led by The Miriam Hospital · Updated on 2025-10-01
80
Participants Needed
1
Research Sites
142 weeks
Total Duration
On this page
Sponsors
T
The Miriam Hospital
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this study is to learn more about omega-3 polyunsaturated fatty acids supplementation on blood lipid profile and platelets in patients with high cholesterol levels. The purpose of this research is to gather information on the safety and effect of two different fish oils, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Participants will: Visit the clinic 3 times during study checkups, tests and blood collection. Randomized to either the EPA or the DHA supplementation group. Be given a 28-day food and activity log.
CONDITIONS
Official Title
Differential Thrombogenesis by EPA and DHA Mediated by HDL
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Fasting triglyceride levels between 150 and 500 mg/dL and HDL cholesterol 40 or less for men or 50 or less for women
- LDL cholesterol greater than 40 mg/dL and up to 130 mg/dL
- Able to provide informed consent and follow study schedules
- Agree to maintain a low fatty fish intake diet of less than 3 servings per week
You will not qualify if you...
- Female who is pregnant, planning pregnancy during the study, or currently breastfeeding
- Weight changes greater than 20% in the past 3 months
- Planning significant changes in diet or exercise
- Malabsorption syndrome or chronic diarrhea
- Use of dietary supplements containing omega-3 fatty acids
- Frequent consumption of omega-3 enriched fish more than 3 times per week
- Abnormal liver, kidney, or thyroid function
- Drug or alcohol abuse within 6 months or significant mental or psychological impairment
- Current smoker
- Taking daily aspirin, NSAIDs, anticoagulants, or corticosteroids
- Known bleeding disorders such as hemophilia
- Allergy or sensitivity to fish, shellfish, or omega-3 supplements
- Requires regular blood transfusions
- No ethnic or racial exclusions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brown University Health - Lipid Clinic
Providence, Rhode Island, United States, 02914
Actively Recruiting
Research Team
W
Wenliang Song, MD
CONTACT
D
Daria Salamevich
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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