Actively Recruiting
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical Alzheimer's Disease
Led by Massachusetts General Hospital · Updated on 2026-03-06
250
Participants Needed
1
Research Sites
52 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the AROMHA Brain Health Test as a way to measure the sense of smell in adults with Subjective Cognitive Concerns, Mild Cognitive Impairment, Mild Behavioral Impairment, and healthy age-matched controls. The study aims to determine if this test can serve as a noninvasive and cost-effective biomarker to help distinguish neurodegenerative disorders from normal aging. This could lead to better early diagnosis and monitoring of these conditions. Participants will complete the AROMHA Brain Health Smell Test, which takes about 45 minutes and is self-administered at home. It involves peeling and sniffing labels on physical smell cards and answering questions through a web-based app about the odors. The test measures odor intensity, identification, discrimination, and episodic olfactory memory, but participants will not receive their individual test results. During the study, researchers will collect data from the smell test and monitor participants' olfactory abilities. The study includes adults aged 18 to 100 years from clinical and community settings, including those diagnosed with cognitive or behavioral impairments and healthy controls. The primary outcome is the performance on the AROMHA Brain Health Test, which researchers will analyze to assess its potential as a predictive tool for neurodegenerative disease. Participation involves a single testing session lasting approximately one hour.
CONDITIONS
Brief Title
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- A clinical or research consensus diagnosis of the patient's condition or control status.
- Individuals that are at least 18 years of age at the time of enrollment.
- Individuals that are no older than 100 years of age at the time of enrollment.
You will not qualify if you...
- Primary pulmonary disease such as severe emphysema or asthma not under good medical control.
- Current sinusitis, common cold, upper respiratory infection, or nasal polyps.
- Current or recent (past 6 months) alcohol or substance dependence.
- Pregnancy.
- Severe cognitive dysfunction that would preclude completion of the olfactory testing.
- An adverse reaction to fragrances such as severe asthmatic attack or nausea.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Single assessment lasting approximately 1 hour
Participants complete the AROMHA Brain Health Test, a self-administered, at-home smell test involving odor sampling and related questions to assess olfactory function.
1 at-home testing session using the smell test device
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02129
Actively Recruiting
Research Team
M
Mark W Albers, MD PhD
A
Alefiya Albers, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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