Actively Recruiting
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
Led by Massachusetts General Hospital · Updated on 2026-03-06
250
Participants Needed
1
Research Sites
242 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to objectively test one's sense of smell, called olfaction, in participants with Subjective Cognitive Concerns (SCC), Mild Cognitive Impairment, Mild Behavioral Impairment (MBI), and age-matched controls. The main question it aims to answer is whether the AROMHA Brain Health Test could serve as a predictive biomarker of neurodegenerative disorders. This understanding will aid in the development of a noninvasive, cost-effective diagnostic tool that reliably and specifically distinguishes disease and normal aging populations. Participants will take the approximately 45-minute AROMHA Brain Health Smell Test where they will peel and sniff labels on the physical smell cards and answer questions on the web-based app relating to what they smelled. Participants will undergo tests for odor intensity, odor identification, odor discrimination, and episodic olfactory memory, but will not be provided the results of these tests.
CONDITIONS
Official Title
Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical or research consensus diagnosis of the participant's condition or control status
- Age between 18 and 100 years at enrollment
You will not qualify if you...
- Primary pulmonary disease such as severe emphysema or asthma not under good medical control
- Current sinusitis, common cold, upper respiratory infection, or nasal polyps
- Current or recent (past 6 months) alcohol or substance dependence
- Pregnancy
- Severe cognitive dysfunction preventing completion of olfactory testing
- Adverse reaction to fragrances causing severe asthmatic attack or nausea
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02129
Actively Recruiting
Research Team
M
Mark W Albers, MD PhD
CONTACT
A
Alefiya Albers, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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