Actively Recruiting
Digital Measures for Clinical Trial Endpoints in Huntington's Disease
Led by University of Rochester · Updated on 2026-01-27
100
Participants Needed
1
Research Sites
66 weeks
Total Duration
On this page
Sponsors
U
University of Rochester
Lead Sponsor
F
Food and Drug Administration (FDA)
Collaborating Sponsor
AI-Summary
What this Trial Is About
MEND-HD is a longitudinal study evaluating the feasibility of passive monitoring of gait and chorea in patients with HD and the meaningfulness of these outcomes for patients with HD and their care partners/support persons. Participants will take part in four virtual visits with study investigators to answer survey questions on movement and cognition, perform in-home movement assessments, and take part in an interview regarding the meaningfulness of gait and chorea in their daily lives. Participant and care partner interviews will be used for symptom mapping and qualitative data analysis to assess the relevance and impact of the targeted symptoms on the participant's daily life. The study may be extended to 3 years to include yearly visits.
CONDITIONS
Official Title
Digital Measures for Clinical Trial Endpoints in Huntington's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age of 25-65 years
- Genetically confirmed adult-onset Huntington's Disease with CAG ≥ 40 (HD-ISS Stage 2 or mild/moderate Stage 3) for HD participants
- English speaking
- Age of 25-65 years for control participants
- English speaking for control participants
- Self-identified support person or family member of enrolled HD participants
- 18 years or older for support persons
- English speaking for support persons
You will not qualify if you...
- Diagnosis of juvenile-onset Huntington's Disease
- History of co-morbid neurological diseases such as stroke, multiple sclerosis, or moderate to severe traumatic brain injury
- Use of an assistive device for walking
- Montreal Cognitive Assessment (MoCA) score of 18 or lower
- Acute or chronic medical conditions significantly affecting gait or mobility, including ankle sprain or fracture, orthopedic, cardiovascular, or psychiatric diseases
- Pregnancy
- Enrollment in a blinded intervention trial at baseline
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Rochester Medical Center
Rochester, New York, United States, 14642
Actively Recruiting
Research Team
S
Sugitha Maheswaran, BS
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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