Digital Smoking Cessation Intervention for Nationally-Recruited American Indians and Alaska Natives: A Full-Scale Randomized Controlled Trial (IndigeQuit)

What this Trial Is About

Researchers are evaluating a new smartphone app called IndigeQuit to help American Indians and Alaska Natives (AI/ANs) quit smoking, comparing it to the existing National Cancer Institute (NCI) QuitGuide app. AI/ANs face much higher rates of smoking-related cancers and deaths compared to other groups, often due to limited access to effective cessation interventions. This trial aims to test whether the IndigeQuit app, designed to teach skills for coping with urges and preventing relapse, is more effective in supporting smoking cessation for this population. Participants are randomly assigned to one of two groups: one uses the IndigeQuit app, which involves creating a personalized quit plan, completing eight content levels, accessing on-demand help, and tracking daily smoking for at least 45 days; the other group uses the NCI QuitGuide app for at least the same duration. After completing the intervention period, participants are followed up at 3, 6, and 12 months to assess ongoing smoking status and app effects. During the study, participants provide information through surveys and may contribute biospecimens for ancillary studies. Researchers measure smoking abstinence rates, focusing on 30-day abstinence at 12 months as the primary outcome, with additional assessments at earlier intervals. The study lasts over a year with multiple follow-up points, ensuring detailed monitoring of smoking behavior changes and app engagement.

A Digital Smoking Cessation Intervention for Helping American Indians and Alaska Natives Quit Smoking, IndigeQuit Trial