Actively Recruiting
Digital Telecytology for Triage of HPV-Positive Women in Cameroon
Led by University Hospital, Geneva · Updated on 2026-04-24
1800
Participants Needed
2
Research Sites
104 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Geneva
Lead Sponsor
E
Ecole Polytechnique Fédérale de Lausanne (EPFL), Campus Biotech
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study evaluates the diagnostic accuracy and feasibility of a same-day cervical cancer screening strategy using HPV self-sampling followed by digital telecytology triage among HPV-positive women in Cameroon. Women aged 30-49 years (or 25-49 years if HIV-positive) will undergo primary HPV testing using the GeneXpert system. HPV-positive women will be managed according to an extended HPV genotyping-based algorithm, including immediate treatment, telecytology triage, or follow-up. Histological assessment serves as the reference standard for the detection of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). Secondary objectives include evaluation of AI-assisted telecytology and visual inspection with acetic acid (VIA), as well as the acceptability of screening and treatment strategies among women and healthcare providers. The study aims to generate evidence to support scalable, WHO-recommended test-triage-treat approaches in low-resource settings
CONDITIONS
Official Title
Digital Telecytology for Triage of HPV-Positive Women in Cameroon
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women aged 30 to 49 years who are HIV-negative
- Women aged 25 to 49 years who are HIV-positive
- Ability to understand the study procedures and voluntarily provide signed informed consent
You will not qualify if you...
- Pregnant at the time of screening
- Previous hysterectomy
- Known cervical cancer
- Symptoms of cervical cancer such as abnormal bleeding or pelvic mass
- Conditions interfering with cervix visualization
- Severe pre-existing medical conditions such as advanced cancer or terminal renal failure
- Inability to comply with the study protocol
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Centre Hospitalier Universitaire de Yaoundé
Yaoundé, Cameroon
Actively Recruiting
2
Yaoundé University Teaching Hospital (CHU)
Yaoundé, Cameroon
Actively Recruiting
Research Team
P
Patrick Petignat, Doctor; Professor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
SCREENING
Number of Arms
1
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