Exploration of a Holistic Management Procedure for Liver Cancer Surveillance to Improve Early Diagnosis in Chinese Population: Single-Center, Prospective Observational Real-World Study

What this Trial Is About

Researchers are evaluating a liver cancer risk stratification management approach to see if it improves early diagnosis rates of liver cancer in high-risk populations in China. The study focuses on patients with conditions such as chronic hepatitis B and C, cirrhosis, and metabolic dysfunction-associated fatty liver disease. This observational real-world study is conducted by Ruijin Hospital and aims to follow participants for up to three years to monitor liver cancer occurrence and early diagnosis effectiveness. Participants are grouped based on liver cancer risk levels according to local guidelines: very high, high, medium, and low risk. They will undergo liver cancer surveillance at intervals of every 3 months, every 6 months, or annually. Surveillance includes tests such as serum AFP and ultrasound exams to monitor liver health. This management aims to standardize follow-up procedures and improve detection timing. During the study, participants will have regular follow-ups for liver cancer surveillance and risk stratification assessments. Researchers will collect data on early diagnosis rates, the distribution of risk levels at screening and follow-up, and the cumulative incidence of liver cancer over three years. The trial will monitor participants for up to four years collectively, including initial screening and long-term follow-up. Safety and compliance will be tracked throughout the study period.

Digitalized Surveillance Management for Liver Cancer Risk Population in Improving Eearly Diagnosis Efficancy in Chinese Population (dSEARCH)