Actively Recruiting
Periodontal Status in Kidney Transplant Patients and the Effectiveness of Adjunctive Diode Laser Therapy
Led by Military Hospital 103 · Updated on 2026-04-16
80
Participants Needed
2
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effectiveness of diode laser-assisted non-surgical periodontal therapy in adults who have received kidney transplants and have periodontitis. This randomized controlled trial aims to compare whether adding diode laser treatment to standard scaling and root planing (SRP) provides better clinical and biological improvements than SRP alone. The study is conducted in parallel groups with 80 participants to understand the impact on oral and systemic health markers. Participants will be randomly assigned to one of two groups: one group will receive full-mouth scaling and root planing combined with adjunctive diode laser therapy, while the other group will receive scaling and root planing alone. The diode laser treatment follows a strict protocol regarding device settings and application. Follow-up visits are planned at baseline, 1 month, 3 months, and 6 months after treatment to monitor progress. During the study, researchers will assess clinical periodontal parameters such as clinical attachment level, probing pocket depth, plaque indices, gingival inflammation, bleeding on probing, and oral hygiene status. Blood tests including platelet count, urea, creatinine, and C-reactive protein will be measured to monitor systemic effects. Subgingival plaque samples will be analyzed using 16S rRNA sequencing to observe microbiome changes at baseline and 1 month. Radiographic imaging will evaluate alveolar bone changes at baseline and 6 months. Participants will be monitored throughout the study timeline for these outcomes and adherence to follow-up visits.
CONDITIONS
Brief Title
Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Kidney transplant recipients aged 18 years or older
- Diagnosis of periodontitis according to the study case definition
- Medically stable and able to undergo non-surgical periodontal treatment
- Willing and able to provide written informed consent and attend follow-up visits
You will not qualify if you...
- Periodontal treatment or systemic antibiotic use within the protocol's exclusion window
- Acute oral infection requiring urgent treatment
- Pregnancy or lactation if excluded by the approved protocol
- Serious systemic condition or clinical instability preventing study participation
- Inability to comply with study procedures or follow-up schedule
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants receive full-mouth scaling and root planing with or without adjunctive diode laser therapy according to the study protocol.
1 treatment visit (in-person)
Duration - 6 months
Participants attend follow-up visits to assess periodontal status, systemic laboratory outcomes, subgingival microbiome, and alveolar bone changes.
4 visits at baseline, 1 month, 3 months, and 6 months (in-person)
Trial Site Locations
Total: 2 locations
1
103 Military Hospital
Hanoi, Hadong, Vietnam, 100000
Actively Recruiting
2
Vietnam Military Medical University
Hanoi, QUẬN HÀ ĐÔNG, Vietnam, 100000
Actively Recruiting
Research Team
T
Thang V Dinh, Principal Investigator
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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