Effectiveness of Diode Laser Therapy Added to Scaling and Root Planing for Treating Periodontitis in Kidney Transplant Patients

What this Trial Is About

Researchers are evaluating the effectiveness of diode laser-assisted non-surgical periodontal therapy in adults who have received kidney transplants and have periodontitis. This randomized controlled trial aims to compare whether adding diode laser treatment to standard scaling and root planing SRP provides better clinical and biological improvements than SRP alone. The study is conducted in parallel groups with 80 participants to understand the impact on oral and systemic health markers. Participants will be randomly assigned to one of two groups one group will receive full-mouth scaling and root planing combined with adjunctive diode laser therapy, while the other group will receive scaling and root planing alone. The diode laser treatment follows a strict protocol regarding device settings and application. Follow-up visits are planned at baseline, 1 month, 3 months, and 6 months after treatment to monitor progress. During the study, researchers will assess clinical periodontal parameters such as clinical attachment level, probing pocket depth, plaque indices, gingival inflammation, bleeding on probing, and oral hygiene status. Blood tests including platelet count, urea, creatinine, and C-reactive protein will be measured to monitor systemic effects. Subgingival plaque samples will be analyzed using 16S rRNA sequencing to observe microbiome changes at baseline and 1 month. Radiographic imaging will evaluate alveolar bone changes at baseline and 6 months. Participants will be monitored throughout the study timeline for these outcomes and adherence to follow-up visits.

Diode Laser-Assisted Periodontal Therapy in Kidney Transplant Recipients