Actively Recruiting
The Direct Oral Anticoagulation Versus Vitamin K Antagonist After Cardiac Surgery Trial
Led by Population Health Research Institute · Updated on 2025-09-29
3500
Participants Needed
19
Research Sites
306 weeks
Total Duration
On this page
Sponsors
P
Population Health Research Institute
Lead Sponsor
H
Hamilton Health Sciences Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The DANCE Trial is a multi-centre, randomized controlled trial comparing the safety of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) in the early period (30 days) after cardiac surgery in patients with atrial fibrillation requiring oral anticoagulation.
CONDITIONS
Official Title
The Direct Oral Anticoagulation Versus Vitamin K Antagonist After Cardiac Surgery Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older at the time of enrollment
- Open heart surgery in the last 10 days
- Atrial fibrillation requiring anticoagulation (including pre-existing or post-operative atrial fibrillation)
- Informed consent from the patient or a substitute decision-maker
You will not qualify if you...
- Mechanical valve replacement
- Antiphospholipid syndrome (triple positive)
- Severe renal failure with creatinine clearance less than 15 ml/min
- Known significant liver disease classified as Child-Pugh B or C
- Presence of left ventricular thrombus
- Ongoing bleeding, bleeding disorders, or bleeding tendency
- Known contraindication to any DOAC or VKA
- Women who are pregnant, breastfeeding, or of childbearing potential
- Surgery including left ventricular assist device implantation or cardiac transplantation
- Previously enrolled in this trial
- Follow-up not possible
- History of moderate or severe mitral valve disease not corrected during the heart surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 19 locations
1
St Vincent's Hospital Melbourne
Fitzroy, Victoria, Australia, 3065
Actively Recruiting
2
Royal Melbourne Hospital, University of Melbourne
Parkville, Victoria, Australia, 3050
Not Yet Recruiting
3
University of Alberta Hospital
Edmonton, Alberta, Canada, T6G 2C8
Actively Recruiting
4
University of British Columbia
Vancouver, British Columbia, Canada, V6T 1Z3
Actively Recruiting
5
St. Boniface Hospital
Winnipeg, Manitoba, Canada, R2H 2A6
Actively Recruiting
6
Saint John Regional Hospital
Saint John, New Brunswick, Canada, E2L4L2
Active, Not Recruiting
7
Health Science Centre
St. John's, Newfoundland and Labrador, Canada, A1B 3V6
Actively Recruiting
8
Health Sciences North Research Institute
Greater Sudbury, Ontario, Canada, P3E 5J1
Actively Recruiting
9
Hamilton General Hospital
Hamilton, Ontario, Canada, L8L 2X2
Actively Recruiting
10
Sunnybrook Hospital
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
11
Toronto General Hospital
Toronto, Ontario, Canada, M5G 2C4
Actively Recruiting
12
Montreal Heart Institute
Montreal, Quebec, Canada, H1T 1C8
Actively Recruiting
13
Hôpital Sacré-Coeur de Montréal
Montreal, Quebec, Canada, H4J1C5
Active, Not Recruiting
14
IUCPQ-ULaval
Québec, Quebec, Canada, G1V 4G5
Actively Recruiting
15
Heart Center Leipzig
Leipzig, Saxony, Germany, 04289
Active, Not Recruiting
16
University Hospital Jena
Jena, Thuringia, Germany, Germany
Actively Recruiting
17
University Hospital Bonn Heart Center
Bonn, Germany, 53127
Active, Not Recruiting
18
West-German Heart and Vascular Center, University of Duisburg-Essen
Essen, Germany, 45147
Not Yet Recruiting
19
University Medical Center Hamburg-Eppendorf
Hamburg, Germany, 20246
Actively Recruiting
Research Team
E
Emilie Belley-Cote, MD, MSc
CONTACT
R
Richard Whitlock, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
FACTORIAL
Primary Purpose
TREATMENT
Number of Arms
2
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